What is new with antibiotic-resistant gonorrhoea in Newcastle, England?

Neisseria gonorrhoeae isolates that were resistant to ciprofloxacin and/or penicillin were analysed to investigate the escalating problem of antibiotic-resistant gonorrhoea in the north east of England. Opa-typing (outer membrane opacity protein) was carried out on isolates resistant to ciprofloxaci...

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Bibliographic Details
Published in:International journal of STD & AIDS 2002-12, Vol.13 (12), p.805-808
Main Authors: ELAWAD, B. B, NARAYANAN, M, PATTMAN, R. S, SANKAR, K. N, FREEMAN, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Outer Membrane Proteins - analysis
Bacterial Typing Techniques - methods
Biological and medical sciences
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Drug Resistance, Bacterial
England - epidemiology
Female
Gonorrhea - drug therapy
Gonorrhea - epidemiology
Gonorrhea - microbiology
Humans
Male
Medical sciences
Middle Aged
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - drug effects
Penicillins - pharmacology
Penicillins - therapeutic use
Pharmacology. Drug treatments
Population Surveillance
Prevalence
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Summary:Neisseria gonorrhoeae isolates that were resistant to ciprofloxacin and/or penicillin were analysed to investigate the escalating problem of antibiotic-resistant gonorrhoea in the north east of England. Opa-typing (outer membrane opacity protein) was carried out on isolates resistant to ciprofloxacin and of nutrient non-requiring (NR) auxotype. In the year 2000 there were 265 cases of gonorrhoea, of which 44 (16.6%) were resistant to penicillin and 12 (4.5%) were resistant or had reduced sensitivity to ciprofloxacin (with only four of these acquired outside the UK). Three (7.5%) of the non-beta-lactamase penicillin-resistant isolates were imported from abroad. By Opa-typing of ciprofloxacin-resistant strains, one pair of the isolates was similar, two were unique and one was similar to the Oldham/Rochdale outbreak strain described early in 2000. This marked increase in the prevalence of indigenous ciprofloxacin resistance requires continued surveillance and may soon necessitate an alteration in our first line treatment.
ISSN:0956-4624
1758-1052
DOI:10.1258/095646202321020044