Decreased Serum Magnesium and Zinc Levels: Atherogenic Implications in Type-2 Diabetes Mellitus in Nigerians

Serum magnesium, zinc and total cholesterol were evaluated in 40 Nigerian patients suffering from type-2 diabetes mellitus (2IM, 19F) and 20 (14M, 6F) apparently normal non diabetic control subjects. The mean age of the diabetic patients was similar to that of controls (p > 0.05). The mean durati...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition and health (Berkhamsted) 2002, Vol.16 (4), p.291-300
Main Authors: Anetor, J.I., Senjobi, A., Agbedana, E.O., Ajose, O.A.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Antioxidants - metabolism
Arteriosclerosis - etiology
Blood Glucose - analysis
Case-Control Studies
Cholesterol - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diet, Atherogenic
Female
Humans
Magnesium - blood
Male
Middle Aged
Nigeria
Risk Factors
Zinc - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Serum magnesium, zinc and total cholesterol were evaluated in 40 Nigerian patients suffering from type-2 diabetes mellitus (2IM, 19F) and 20 (14M, 6F) apparently normal non diabetic control subjects. The mean age of the diabetic patients was similar to that of controls (p > 0.05). The mean duration of the disease was (4.7 + 0.7 SEM) in these patients. Fasting blood glucose and total cholesterol were significantly higher in diabetics than in non diabetic control subjects (p > 0.001). The serum total cholesterol showed inter-group variation when the patients were classified into four different age groups. In contrast, the serum level of magnesium (Mg) and zinc (Zn) were significantly lower in diabetics than in controls (p > 0.001). There were no significant correlation between glucose and the minerals, Mg. and Zn. Serum total cholesterol showed a significant positive correlation with magnesium (r = 0.6: p > 0.001), while the correlation with zinc was not significant. In type-2 diabetic mellitus the concentration of both Mg and Zn levels were significantly reduced, probably suggesting lower antioxidant status in this condition. The implication is the greater susceptibility to LDL-cholesterol oxidation. The attendant risk of development of premature Coronary Heart Disease is discussed. Magnesium and zinc are nutritional minerals that play crucial roles in the regulation of carbohydrate and lipid metabolism.
ISSN:0260-1060
2047-945X
DOI:10.1177/026010600201600403