Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand

The epidemiology of chronic diarrhoea in adults with late-stage HIV infection was investigated in a prospective study in Bangkok, Thailand. During this investigation, 34 Cryptosporidium isolates were obtained from the faeces of 36 patients, with mean CD4(+) counts of only 14 x 10(6) CD4(+) cells/lit...

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Bibliographic Details
Published in:Annals of tropical medicine and parasitology 2002-12, Vol.96 (8), p.797-802
Main Authors: GATEI, W, SUPUTTAMONGKOL, Y, WAYWA, D, ASHFORD, R. W, BAILEY, J. W, GREENSILL, J, BEECHING, N. J, HART, C. A
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
Cryptosporidiosis - complications
Cryptosporidiosis - parasitology
Cryptosporidium - classification
Cryptosporidium parvum - classification
Cryptosporidium parvum - isolation & purification
Diarrhea - complications
Diarrhea - parasitology
Feces - parasitology
HIV Infections - complications
HIV Infections - parasitology
Human viral diseases
Humans
Infectious diseases
Medical sciences
Phylogeny
Polymorphism, Restriction Fragment Length
Prospective Studies
Thailand - epidemiology
Tropical medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Zoonoses - parasitology
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Summary:The epidemiology of chronic diarrhoea in adults with late-stage HIV infection was investigated in a prospective study in Bangkok, Thailand. During this investigation, 34 Cryptosporidium isolates were obtained from the faeces of 36 patients, with mean CD4(+) counts of only 14 x 10(6) CD4(+) cells/litre (range = 2 x 10(6) - 53 x 10(6)/litre), who had symptomatic cryptosporidiosis. Genotyping of these isolates, by RFLP analysis and DNA sequencing of the hypervariable region of the 18S rRNA gene, indicated that only 17 (50%) were of the C. parvum human genotype. The rest were of C. meleagridis (seven), the C. parvum 'bovine' genotype (five), C. felis (three) and C. canis (two). Extensive genotypic heterogeneity was observed among the C. parvum isolates, and two other isolates, one of C. meleagridis and the other of C. felis, produced atypical restriction patterns and were only identified by sequencing. This appears to represent the first report of C. canis and the 'bovine' genotype of C. parvum in HIV-infected Thai patients.
ISSN:0003-4983
1364-8594
DOI:10.1179/000349802125002202