Electroencephalographic sleep and natural killer activity in depressed patients and control subjects

Insomnia is associated with a reduction of natural killer (NK) activity in depression independent of the severity of other depressive symptoms. This study extends these findings by exploring the relationship between objective electroencephalographic (EEG) assessment of sleep and values of NK activit...

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Bibliographic Details
Published in:Psychosomatic medicine 1992, Vol.54 (1), p.10-21
Main Authors: IRWIN, M, SMITH, T. L, GILLIN, J. C
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Depressive Disorder - complications
Depressive Disorder - diagnosis
Depressive Disorder - physiopathology
Educational Status
Electroencephalography
Humans
Interleukin-1 - immunology
Killer Cells, Natural - immunology
Male
Medical sciences
Mood disorders
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sleep - physiology
Sleep Initiation and Maintenance Disorders - complications
Sleep Initiation and Maintenance Disorders - diagnosis
Sleep Initiation and Maintenance Disorders - physiopathology
Sleep, REM - physiology
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Summary:Insomnia is associated with a reduction of natural killer (NK) activity in depression independent of the severity of other depressive symptoms. This study extends these findings by exploring the relationship between objective electroencephalographic (EEG) assessment of sleep and values of NK activity in depressed patients (n = 23) and in control subjects (n = 17). The sleep EEG parameters total sleep time, sleep efficiency, and duration of nonREM sleep were each positively correlated with NK activity in the depressed patients and in the control subjects, demonstrating similar relationships between the amount of sleep and NK activity in the separate groups. These observations support the hypothesis that sleep measures are associated with NK cytotoxicity, independent of the effects of severity of depressive symptoms or the presence of a mood disorder.
ISSN:0033-3174
1534-7796
DOI:10.1097/00006842-199201000-00002