No increased risk for invasive bacterial infection found following diphtheria-tetanus-pertussis immunization

During the acellular pertussis vaccine trial in Sweden, 4 children who were randomly assigned to receive the vaccine died of suspected or confirmed bacterial infections compared to 1 expected. There were no deaths in the placebo arm. This raised concern about the role of pertussis immunization in th...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 1992-04, Vol.89 (4 Pt 1), p.640-642
Main Authors: Griffin, M R, Taylor, J A, Daugherty, J R, Ray, W A
Format: Article
Language:English
Subjects:
Bacterial infections
Bacterial Infections - epidemiology
Child
Child, Preschool
Children
Cohort Studies
Complications and side effects
Diphtheria-Tetanus-Pertussis Vaccine
Diphtheria-tetanus-pertussis vaccines
DPT vaccine
Evaluation
Follow-Up Studies
Haemophilus Infections - epidemiology
Haemophilus influenzae
Humans
Immunization
Incidence
Infant
Physiological aspects
Pneumococcal Infections - epidemiology
Population Surveillance
Risk Factors
Tennessee - epidemiology
Time Factors
Vaccination - statistics & numerical data
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During the acellular pertussis vaccine trial in Sweden, 4 children who were randomly assigned to receive the vaccine died of suspected or confirmed bacterial infections compared to 1 expected. There were no deaths in the placebo arm. This raised concern about the role of pertussis immunization in the development of serious infections. Through linking computerized immunization records with an active surveillance system for serious bacterial infections in children, the authors studied a cohort of 64,591 children immunized through Tennessee county health clinics who had a total of 158 episodes of invasive bacterial infections after a diphtheria and tetanus toxoids and pertussis (DTP) immunization. There were 8 invasive bacterial infections that occurred within the first 7 days following DTP immunization, yielding an age-adjusted relative risk (95% confidence interval) of 1.0 (0.5 to 2.0), compared to the interval 29 or more days following immunization. There were 7 and 20 infections in the 8- through 14- and 15- through 28-day intervals following DTP immunization, giving relative risks of 0.8 (0.4 to 1.7) and 1.2 (0.7 to 1.9), respectively. These data provide reassurance that the use of DTP vaccine is not followed by a large increased risk of serious bacterial infections.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.89.4.640