Efficacy of an Escherichia coli J5 mastitis vaccine in an experimental challenge trial

An Escherichia coli (O111:B4) J5 bacterin was tested for efficacy in reducing M and severity of clinical coliform mastitis in an experimental challenge trial. Ten cows were immunized at drying off, 30 d after drying off, and at calving. Ten control cows were not immunized. Right front quarters of al...

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Bibliographic Details
Published in:Journal of dairy science 1992-02, Vol.75 (2), p.415-422
Main Authors: Hogan, J.S. (Ohio State University, Wooster, OH), Weiss, W.P, Todhunter, D.A, Smith, K.L, Schoenberger, P.S
Format: Article
Language:English
Subjects:
Animals
Bacterial Vaccines
Body Temperature
Cattle
Colony Count, Microbial - veterinary
CONTEO DE CELULAS
Eating
ESCHERICHIA
Escherichia coli
Escherichia coli - immunology
Escherichia coli Infections - prevention & control
Escherichia coli Infections - veterinary
Escherichia coli Vaccines
Female
Glutathione Peroxidase - blood
Immunoglobulins - analysis
Immunoglobulins - blood
Lactation
MAMMITE BOVINE
MASTITIS BOVINA
Mastitis, Bovine - prevention & control
Milk - immunology
Milk - microbiology
Milk - secretion
NUMERATION CELLULAIRE
PATHOGENESE
PATOGENESIS
RENDEMENT LAITIER
RENDIMIENTO LECHERO
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
SERUM SANGUIN
SUERO SANGUINEO
TEMPERATURA DEL CUERPO
TEMPERATURE CORPORELLE
VACAS LECHERAS
VACCIN VIVANT
VACCINATION
Vaccination - veterinary
VACHE LAITIERE
VACUNA VIVA
VACUNACION
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Summary:An Escherichia coli (O111:B4) J5 bacterin was tested for efficacy in reducing M and severity of clinical coliform mastitis in an experimental challenge trial. Ten cows were immunized at drying off, 30 d after drying off, and at calving. Ten control cows were not immunized. Right front quarters of all cows were infused with a heterologous strain of E. coli approximately 30 d after calving. Vaccinated cows had lower bacterial counts in milk and lower rectal temperatures than unvaccinated controls following intramammary challenge. Milk production and DMI were more depressed in controls than in vaccinated cows. Milk SCC did not differ between experimental groups. Mean serum IgG titer to whole cell E. coli J5 was significantly greater in vaccinated than in unvaccinated cows at 30 d after drying off, day of challenge, and 7 d postchallenge. Milk IgG titer to E colt J5 was higher at challenge in vaccinated than in control cows. Vaccination with die E. coli J5 bacterin did not prevent M but did reduce severity of clinical signs following in experimental challenge with a heterologous E. coli strain
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.s0022-0302(92)77777-7