Trichomonas vaginalis: microtubule cytoskeleton distribution using fluorescent taxoid

Trichomonas vaginalis is a flagellated parasitic protist of the human urogenital tract. The parasite has a poorly known cytoskeleton formed by an axostyle and a pelta, which are formed by stable structures such as microtubules, essential for the maintenance of cell shape and organization. FLUTAX-2 i...

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Bibliographic Details
Published in:Experimental parasitology 2002-10, Vol.102 (2), p.113-116
Main Authors: Lecke, Sheila B, Tasca, Tiana, Souto, André A, De Carli, Geraldo A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Centrosome - ultrastructure
Cytoskeleton - ultrastructure
Flagella - ultrastructure
Fluorescent Dyes - chemistry
Fundamental and applied biological sciences. Psychology
Humans
Microscopy, Fluorescence
Microtubules - ultrastructure
Paclitaxel - analogs & derivatives
Paclitaxel - chemistry
Protozoa
Systematics. Geographical distribution. Morphology. Cytology
Taxoids
Trichomonas vaginalis - ultrastructure
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Summary:Trichomonas vaginalis is a flagellated parasitic protist of the human urogenital tract. The parasite has a poorly known cytoskeleton formed by an axostyle and a pelta, which are formed by stable structures such as microtubules, essential for the maintenance of cell shape and organization. FLUTAX-2 is an active fluorescent derivative of Taxol, binds to αβ-tubulin dimer polymerized. In this paper we present the analysis of microtubule distribution in living trophozoites of T. vaginalis using FLUTAX-2. Index Descriptors and Abbreviations: Trichomonas vaginalis; microtubule cytoskeleton; fluorescent taxoid; FLUTAX.
ISSN:0014-4894
1090-2449
DOI:10.1016/S0014-4894(03)00030-4