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Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis

Acetylpyridine benzoyl hydrazone (APBH) 1 and its copper complex [{(APBH)CuCl} 2]·(EtOH) 2 were structurally characterized by elemental analysis, magnetic measurements, spectroscopy, electrochemistry and single crystal X-ray diffraction studies. The ligand assumes Z-isomeric form and planar geometry...

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Published in:Bioorganic & medicinal chemistry letters 2003-01, Vol.13 (1), p.51-55
Main Authors: Patole, Jayendra, Sandbhor, Uday, Padhye, Subhash, Deobagkar, Dileep N., Anson, Christopher E., Powell, Annie
Format: Article
Language:English
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Summary:Acetylpyridine benzoyl hydrazone (APBH) 1 and its copper complex [{(APBH)CuCl} 2]·(EtOH) 2 were structurally characterized by elemental analysis, magnetic measurements, spectroscopy, electrochemistry and single crystal X-ray diffraction studies. The ligand assumes Z-isomeric form and planar geometry in solid state, coordinating through pyridyl nitrogen, azomethine nitrogen and the carbonyl oxygen of the benzoyl group. The copper complex is dimeric and has a distorted octahedral geometry in which the two copper atoms are bridged by two chloride atoms. Antimycobacterial screening of ligand and its copper compound against Mycobacterium smegmatis shows clear enhancement in the antitubercular activity upon copper complexation. Acetylpyridine benzoylhydrazone (APBH) 1 and its copper complex [{(APBH)CuCl} 2] (EtOH) ( 2) have been structurally characterized. The copper complex shows 3-fold greater antimycobacterial activity when tested against Mycobacterium smegmatis.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00855-7