Antimicrobial constituents from the rhizomes of Rheum emodi

The bioassay-guided chemical examination of the rhizomes of R. emodi resulted in the isolation of two new oxanthrone esters, revandchinone-1, revandchinone-2, a new anthraquinone ether revandchinone-3 and a new oxanthrone ether, revandchinone-4. Their structures were established based on spectroscop...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2003, Vol.62 (2), p.203-207
Main Authors: Suresh Babu, K, Srinivas, P.V, Praveen, B, Hara Kishore, K, Suryanarayana Murty, U, Madhusudana Rao, J
Format: Article
Language:English
Subjects:
Anthraquinones - chemistry
Anthraquinones - isolation & purification
Anthraquinones - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Chemical constitution
Chrysophanol
Esters - chemistry
Esters - isolation & purification
Esters - pharmacology
Ethers - chemistry
Ethers - isolation & purification
Ethers - pharmacology
Fundamental and applied biological sciences. Psychology
General pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Physcion
Plant physiology and development
Polygonaceae
Revandchinone-1
Revandchinone-2
Revandchinone-3
Revandchinone-4
Rheum - chemistry
Rheum emodi
Rhizome - chemistry
Rhubarb
β-Asarone
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Summary:The bioassay-guided chemical examination of the rhizomes of R. emodi resulted in the isolation of two new oxanthrone esters, revandchinone-1, revandchinone-2, a new anthraquinone ether revandchinone-3 and a new oxanthrone ether, revandchinone-4. Their structures were established based on spectroscopic and degradative evidence. Occurrence of oxanthrone ether is reported for the first time. The anti bacterial and anti fungal activity of the isolates is studied. The bioassay-guided fractionation of the rhizomes of Rheum emodi afforded two oxanthrone esters, revandchinone-1 ( 1), revandchinone-2 ( 2), an anthraquinone ether, revandchinone-3 ( 3) and an oxanthrone ether, revandchinone-4 ( 4). The anti bacterial and anti fungal properties of the new compounds were established.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(02)00571-X