Tissue response to polyanionic collagen: elastin matrices implanted in rat calvaria

The tissue response to polyanionic collagen matrices, prepared from bovine pericardium and implanted subperiosteally in rat calvaria, was studied. The materials were implanted in 72 male rats ( Rattus norvegicus, albinus, Holtzman), randomly divided into four groups: GI-MBP hydrolyzed for 24 h; GII-...

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Bibliographic Details
Published in:Biomaterials 2003, Vol.24 (2), p.207-212
Main Authors: Rosa, Fabiana Paim, Lia, Raphael Carlos Comelli, de Souza, Kaline Olı́mpia Fernandes, Goissis, Gilberto, Marcantonio, Elcio
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials
Bone substitute
Cattle
Collagen
Elastin
Inflammation
Male
Osteogenesis
Polyanionic collagen
Rats
Rats, Sprague-Dawley
Skull - physiopathology
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Summary:The tissue response to polyanionic collagen matrices, prepared from bovine pericardium and implanted subperiosteally in rat calvaria, was studied. The materials were implanted in 72 male rats ( Rattus norvegicus, albinus, Holtzman), randomly divided into four groups: GI-MBP hydrolyzed for 24 h; GII-MBP hydrolyzed for 36 h; GIII-MBP hydrolyzed for 48 h; GIV-native MBP. The materials were explanted after 15, 30 and 60 days and analyzed by routine histological procedures. Except for group IV (native bovine pericardium), polyanionic collagen from groups GI, GII and GIII showed low inflammatory reaction associated with bone formation, partially or completely integrated to the cranial bone; group GIV was characterized by an intense inflammatory reaction with occasional dystrophic mineralization and with occasional bone formation at 60 days when there was a decrease in the inflammatory reaction. Thus, the MBP from groups I, II and III were biologically compatible, enhancing bone formation with a slight delay at 60 days in GII.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(02)00292-2