Three polymorphic genes encoding a depressant toxin from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus

Four clones encoding the insect depressant toxin LqqIT2 have been isolated from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus using RT-PCR. The four clones have been sequenced and their deduced amino acid sequences have been compared with the original amino acid sequence determined f...

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Bibliographic Details
Published in:Toxicon (Oxford) 2003, Vol.41 (1), p.109-113
Main Authors: Zaki, Tamer I, Maruniak, James E
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Cloning, Molecular
DNA Primers
Fundamental and applied biological sciences. Psychology
Gene polymorphism
Genetics of eukaryotes. Biological and molecular evolution
Invertebrata
Molecular Sequence Data
Polymorphism, Genetic
Reverse Transcriptase Polymerase Chain Reaction
RT-PCR
Scorpion
Scorpion Venoms - genetics
Scorpions
Toxin
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Summary:Four clones encoding the insect depressant toxin LqqIT2 have been isolated from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus using RT-PCR. The four clones have been sequenced and their deduced amino acid sequences have been compared with the original amino acid sequence determined from the purified LqqIT2 protein and polymorphisms have been shown. This study succeeded in isolating more than one copy of the LqqIT2 gene, although only one amino acid sequence has been identified from the purified LqqIT2 toxin.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(02)00242-8