Matrix metalloproteinases-9 and -2 in secondary vasculitic neuropathies

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteinases that play an important role in inflammation and tissue degradation. MMP-9 and MMP-2 are gelatinases that have been implicated in the degradation of the blood-brain or blood-nerve barrier. We present an immunohistochemica...

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Bibliographic Details
Published in:Acta neuropathologica 2003, Vol.105 (1), p.37-42
Main Authors: RENAUD, Susanne, ERNE, Beat, FUHR, Peter, SAID, Gérard, LACROIX, Catherine, STECK, Andreas J, LEPPERT, David
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies
Biological and medical sciences
Biopsy
Blood vessels
Demyelinating Diseases - enzymology
Disease
Female
Humans
Male
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Medical sciences
Middle Aged
Nerve Tissue - enzymology
Nervous system involvement in other diseases. Miscellaneous
Neurology
Neurosciences
Patients
Polyneuropathies - enzymology
Rheumatoid arthritis
Tissue Distribution
Vasculitis - enzymology
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Summary:Matrix metalloproteinases (MMPs) are a family of zinc-dependent endoproteinases that play an important role in inflammation and tissue degradation. MMP-9 and MMP-2 are gelatinases that have been implicated in the degradation of the blood-brain or blood-nerve barrier. We present an immunohistochemical study on 11 nerve biopsy samples of inflammatory and non-inflammatory polyneuropathies. Perineurium and endothelium were positive for MMP-2 in all tissue sections. In addition, there was a specific up-regulation of MMP-2 in stromal cells of chronic inflammatory demyelinating polyneuropathy (CIDP) and even more in vasculitic neuropathies. MMP-9-positive cells were detected in vessel walls, infiltrates, epineurium and endoneurium of vasculitic neuropathies. In CIDP, MMP-9-positive cells were prominent in vessel walls. Only a few MMP-9-positive cells were detected in noninflammatory controls in blood vessels and adhering to vessel walls. Double staining indicated that the infiltrating cells were T cells and macrophages. Our findings suggest that MMP-9 plays an important role in inflammatory peripheral neuropathy probably as means for inflammatory cell invasion.
ISSN:0001-6322
1432-0533
DOI:10.1007/s00401-002-0607-8