Imipramine effect on hypothalamic-pituitary-adrenal axis response to hypoglycemia

Six control subjects underwent an insulin tolerance test before and after the administration of therapeutic doses of imipramine hydrochloride for 10 days to investigate effects of tricyclic antidepressants on hypothalamic-pituitary-adrenal axis response to hypoglycemia. The mean steady-state tricycl...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 1992, Vol.41 (1), p.45-52
Main Authors: Kathol, Roger G., Jaeckle, Richard, Wysham, Carol, Sherman, Barry M.
Format: Article
Language:English
Subjects:
adrenocorticotropic hormone
Adrenocorticotropic Hormone - blood
Adult
Antidepressant drugs
Blood Glucose - metabolism
cortisol
Female
glucose
Humans
Hydrocortisone - blood
hypoglycemia
Hypoglycemia - blood
Hypothalamo-Hypophyseal System - drug effects
Imipramine - pharmacology
insulin
Insulin - blood
Male
Pituitary-Adrenal System - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six control subjects underwent an insulin tolerance test before and after the administration of therapeutic doses of imipramine hydrochloride for 10 days to investigate effects of tricyclic antidepressants on hypothalamic-pituitary-adrenal axis response to hypoglycemia. The mean steady-state tricyclic blood level was 141 (SD = 66) ng/ml. Baseline levels of glucose, cortisol, and adrenocorticotropic hormone (ACTH) were not affected by the administration of imipramine. After administration of imipramine for 10 days, subjects uniformly had a significantly lower glucose nadir than before its administration (before imipramine: mean = 32 mg/dl; SD = 5; after imipramine: mean = 24 mg/dl; SD = 6). There was no difference in ACTH or cortisol response before and after the administration of imipramine. These findings suggest that imipramine hydrochloride increases sensitivity to the hypoglycemic effects of insulin, but does not alter the counterregulatory response of ACTH and cortisol.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(92)90017-W