The automated radiosynthesis of [ 18F]FP-TZTP

[ 18F]FP-TZTP (3-(3-(3-[ 18F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) is a muscarinic ligand that displays in vivo selectivity for the M2 subtype. We have developed a one-step radiosynthesis of [ 18F]FP-TZTP that can be conducted with an automated synthesis unit....

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Bibliographic Details
Published in:Nuclear medicine and biology 2003, Vol.30 (1), p.73-77
Main Authors: Kiesewetter, Dale O, Vuong, Bik-kee, Channing, Michael A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Equipment Design
Fluorine Radioisotopes - chemistry
Fluorine-18
FP-TZTP
Isotope Labeling - instrumentation
Isotope Labeling - methods
Medical sciences
Muscarinic receptors
Pyridines - chemical synthesis
Quality Control
Radiopharmaceuticals - chemical synthesis
Robotics - instrumentation
Thiazoles - chemical synthesis
Tomography, Emission-Computed - methods
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Summary:[ 18F]FP-TZTP (3-(3-(3-[ 18F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) is a muscarinic ligand that displays in vivo selectivity for the M2 subtype. We have developed a one-step radiosynthesis of [ 18F]FP-TZTP that can be conducted with an automated synthesis unit. A number of hardware and software modifications to a Nuclear Interface C-11 Methylation System provided the equipment for the automated radiosynthesis. The manual synthesis produced [ 18F]FP-TZTP in a radiochemical yield of 23.4% ± 4.3% (EOS, n = 69) with a specific activity of 4377 ± 2011 mCi/μmol (EOB, n = 100). The automated synthesis unit provided the product in a radiochemical yield of 18.8% ± 2.4% (EOS, n = 25) with a specific activity of 4112 ± 2572 mCi/μmol (EOB, n = 25).
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(02)00354-2