Cultivation of primmorphs from the marine sponge Suberites domuncula: morphogenetic potential of silicon and iron

Marine demosponges (phylum Porifera) are rich sources for potent bioactive compounds. With the establishment of the primmorph system from sponges, especially from Suberites domuncula, the technology to cultivate sponge cells in vitro improved considerably. This progress was possible after the elucid...

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Bibliographic Details
Published in:Journal of Biotechnology 2003-01, Vol.100 (2), p.93-108
Main Authors: Le Pennec, Gaël, Perovic, Sanja, Ammar, Mohammed Shokry A, Grebenjuk, Vladislav A, Steffen, Renate, Brümmer, Franz, Müller, Werner E.G
Format: Article
Language:English
Subjects:
Animals
aquaculture techniques
Biological and medical sciences
Bioreactors
Canals
Cell Aggregation - physiology
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Cell Division - drug effects
Cell Division - physiology
Demospongiae
Ecosystem
Evolution
Ferritins - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Growth factors
Growth Substances - metabolism
Iron - pharmacology
Marine
Metazoa
Morphogenesis - physiology
Porifera
Porifera - classification
Porifera - cytology
Porifera - drug effects
Porifera - growth & development
Primmorphs
Silicatein
Silicates - pharmacology
Species Specificity
sponge culture
Sponges
Suberites domuncula
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Summary:Marine demosponges (phylum Porifera) are rich sources for potent bioactive compounds. With the establishment of the primmorph system from sponges, especially from Suberites domuncula, the technology to cultivate sponge cells in vitro improved considerably. This progress was possible after the elucidation that sponges are provided with characteristic metazoan cell adhesion receptors and extracellular matrix molecules which allow their cells a positioning in a complex organization pattern. This review summarizes recent data on the cultivation of sponges in aquaria and—with main emphasis—of primmorphs in vitro. It is outlined that silicon and Fe(+++) contribute substantially to the formation of larger primmorphs (size of 10 mm) as well as of a canal system in primmorphs; canals are probably required for an improved oxygen and food supply. We conclude that the primmorph system will facilitate a sustainable use of sponges in the production of bioactive compounds; it may furthermore allow new and hitherto not feasible insights into basic questions on the origin of Metazoa.
ISSN:0168-1656
1873-4863
DOI:10.1016/S0168-1656(02)00259-6