Expression of Arnt and Arnt2 mRNA in Developing Murine Tissues

The basic helix-loop-helix (bHLH-PAS) proteins aryl hydrocarbon receptor nuclear translocator (Arnt) and Arnt2 are transcriptional regulators that function as dimerizing partners for several bHLH-PAS proteins and also some nonrelated partners. They are involved in various biological functions, inclu...

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Bibliographic Details
Published in:The journal of histochemistry and cytochemistry 2003-01, Vol.51 (1), p.41-54
Main Authors: Aitola, Marjo H, Pelto-Huikko, Markku T
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Aryl Hydrocarbon Receptor Nuclear Translocator
Basic Helix-Loop-Helix Transcription Factors
DNA-Binding Proteins
Embryonic and Fetal Development
Fetus - metabolism
Gene Expression Regulation, Developmental
Helix-Loop-Helix Motifs
In Situ Hybridization
Mice
Organ Specificity
Receptors, Aryl Hydrocarbon
RNA, Messenger - biosynthesis
Transcription Factors - biosynthesis
Transcription Factors - genetics
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Summary:The basic helix-loop-helix (bHLH-PAS) proteins aryl hydrocarbon receptor nuclear translocator (Arnt) and Arnt2 are transcriptional regulators that function as dimerizing partners for several bHLH-PAS proteins and also some nonrelated partners. They are involved in various biological functions, including regulation of developmental genes. In earlier studies, the developmental expression of Arnt was reported to be almost ubiquitous, whereas Arnt2 expression has been shown to be more limited, comprising neuronal tissues as the main site of expression. Here we provide a detailed description of the expression of Arnt and Arnt2 mRNA in mouse tissues during embryonic and early postnatal development. Arnt and also Arnt2 transcripts, in contrast to earlier reports, are shown to be expressed more widely during development yet show a temporally and spatially specific pattern.
ISSN:0022-1554
1551-5044
DOI:10.1177/002215540305100106