Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease

We examined the associations of postmortem neocortical immunoreactivities for microglia, astrocytes, Aβ and Tau with cognitive changes in clinically characterized subjects with pathological diagnoses (CERAD classification) of definite AD (9), possible AD (15) and age-matched controls (11). By measur...

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Bibliographic Details
Published in:Neurobiology of aging 2003-03, Vol.24 (2), p.321-331
Main Authors: Vehmas, Anne K, Kawas, Claudia H, Stewart, Walter F, Troncoso, Juan C
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - immunology
Alzheimer Disease - pathology
Amyloid beta-Peptides - analysis
Astrocyte
Astrocytes - pathology
Aβ-peptide
Biological and medical sciences
Cognition Disorders - immunology
Cognition Disorders - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Female
Humans
Immunity
Immunohistochemistry
Male
Medical sciences
Microglia
Microglia - pathology
Neurology
Neuropil - chemistry
Neuropil - pathology
Plaque, Amyloid - immunology
Plaque, Amyloid - pathology
tau Proteins - analysis
Tau-protein
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Summary:We examined the associations of postmortem neocortical immunoreactivities for microglia, astrocytes, Aβ and Tau with cognitive changes in clinically characterized subjects with pathological diagnoses (CERAD classification) of definite AD (9), possible AD (15) and age-matched controls (11). By measuring the fractional area (FA) of immunoreactivity, we found that Aβ deposits appear early in the pathogenesis of Aβ, but cannot account for cognitive decline. We found a significant increases in FA for microglia in possible AD cases (nondemented) compared to controls ( P
ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(02)00090-8