Response of the insulin-like growth factor system to vitamin A depletion and repletion in rats

• Published in: Journal of Nutritional Science and Vitaminology 2002, Vol.48(6), pp.453-460
• Main Authors: Fu, Z. (Tokyo Univ. (Japan)), Yoneyama, M, Noguchi, T, Kato, H
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blotting, Northern; Enzymes. Coenzymes. Vitamins. Pigments; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; IGF binding protein; IGF receptor; INSULIN-LIKE GROWTH FACTOR; insulin-like growth factor (IGF); Insulin-Like Growth Factor Binding Proteins - biosynthesis; Insulin-Like Growth Factor Binding Proteins - genetics; Insulin-Like Growth Factor Binding Proteins - metabolism; Male; Metabolisms and neurohumoral controls; Random Allocation; rat; RATS; Rats, Wistar; RETINOL; RNA, Messenger - chemistry; RNA, Messenger - genetics; Somatomedins - biosynthesis; Somatomedins - genetics; Somatomedins - metabolism; Tissue Distribution; Tretinoin - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamin A; Vitamin A - administration & dosage; Vitamin A - analogs & derivatives; Vitamin A - blood; Vitamin A - metabolism; Vitamin A Deficiency - genetics; Vitamin A Deficiency - metabolism
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.48.453

Vitamin A (VA) and insulin-like growth factors (IGF) are important regulators of a wide range of physiological processes. To investigate the IGF system's involvement in the physiological actions of VA, we examined the effects of VA status on components of the IGF system in rats. Male rats (3-wk-old) fed a VA-deficient diet for 11 wk developed VA deficiency, as confirmed by the depletion of serum retinyl and hepatic retinyl palmitate. Rats fed the VA-deficient diet had significantly lower body weight (p