The vegetalizing factor A member of the evolutionarily highly conserved activin family

The mesoderm and endoderm inducing vegetalizing factor was partially sequenced after BrCN cleavage. A sequence which is highly conserved in activin A near the C-terminal end was identified. This shows that the factor belongs to the activin family. The activins are not confined to embryos and gonads,...

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Bibliographic Details
Published in:FEBS letters 1992-03, Vol.300 (2), p.123-126
Main Authors: Tiedemann, Heinz, Lottspeich, Friedrich, Davids, Michael, Knöchel, Sigrun, Hoppe, Peter, Tiedemann, Hildegard
Format: Article
Language:English
Subjects:
activin
Activin A
Activins
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Biological Evolution
Calf kidney
Calf liver
Cattle
Chick Embryo
chick embryos
Chicken embryo
Embryonic induction
Fundamental and applied biological sciences. Psychology
gene families
Inhibins - chemistry
Inhibins - genetics
Inhibins - isolation & purification
Inhibins - pharmacology
Kidney - chemistry
Liver - chemistry
Molecular Sequence Data
Protein hormones. Growth factors. Cytokines
Proteins
Triturus
Vegetalizing factor
Xenopus laevis
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Summary:The mesoderm and endoderm inducing vegetalizing factor was partially sequenced after BrCN cleavage. A sequence which is highly conserved in activin A near the C-terminal end was identified. This shows that the factor belongs to the activin family. The activins are not confined to embryos and gonads, but widely distributed in other tissues like calf kidney and calf liver. Functional aspects are discussed.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)80178-J