Clinical trial of esmolol-induced controlled hypotension with or without acute normovolemic hemodilution in spinal surgery

Background: Drug‐induced controlled hypotension (CH) combined with acute normovolemic hemodilution (ANH) is being widely used for blood conservation in surgical patients. The purpose of this study was to investigate the efficacy and safety of esmolol‐induced CH combined with ANH (hematocrit down to...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2003-01, Vol.47 (1), p.74-78
Main Authors: Lim, Y. J., Kim, C. S., Bahk, J. H., Ham, B. M., Do, S. H.
Format: Article
Language:English
Subjects:
acute normovolemic hemodilution
Adrenergic beta-Antagonists
Aged
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
blood conservation
Blood Loss, Surgical - prevention & control
Blood Pressure - drug effects
Cardiac Output - drug effects
Cardiovascular Diseases - complications
Cardiovascular Diseases - physiopathology
controlled hypotension
Decompression, Surgical
esmolol
Female
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Heart Rate - drug effects
Hemodilution
Hemodynamics - drug effects
Humans
Hypotension, Controlled
Male
Medical sciences
Middle Aged
Oxygen Consumption - drug effects
Oxygen Consumption - physiology
Propanolamines
Spinal Cord - surgery
Spinal Fusion
spinal surgery
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Summary:Background: Drug‐induced controlled hypotension (CH) combined with acute normovolemic hemodilution (ANH) is being widely used for blood conservation in surgical patients. The purpose of this study was to investigate the efficacy and safety of esmolol‐induced CH combined with ANH (hematocrit down to 28%). Methods: Thirty patients who were scheduled to receive spinal surgery were randomly divided into two groups: an esmolol‐induced CH alone group (esmolol group, n=15) and a CH‐ANH combined group (E‐ANH group, n=15). Controlled hypotension was induced with esmolol 500 µg/kg, followed by a continuous infusion of 0–300 µg/kg/min to maintain mean arterial pressure at 55–65 mmHg. Results: The mean infusion rate of esmolol in the esmolol‐ANH group was 46±6 µg/kg/min (mean±SD), which was significantly lower than the 77±9 µg/kg/min used in the esmolol group (P
ISSN:0001-5172
1399-6576
DOI:10.1034/j.1399-6576.2003.470113.x