Wegener's granulomatosis masquerading as pancreatic carcinoma

A 62-year-old male presented with painless jaundice and solitary pulmonary and pancreatic masses. An extensive evaluation revealed Wegener's granulomatosis as the etiology. His pancreatic mass and jaundice responded to temporary stenting and therapy with cyclophosphamide and prednisone. While p...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1992-05, Vol.37 (5), p.702-704
Main Authors: O'NEIL, K. M, JONES, D. M, LAWSON, J. M
Format: Article
Language:English
Subjects:
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies - analysis
Biological and medical sciences
Biomarkers, Tumor - chemistry
Carcinoma - diagnosis
Carcinoma - pathology
Cholangiopancreatography, Endoscopic Retrograde
Cholestasis, Extrahepatic - diagnosis
Cholestasis, Extrahepatic - pathology
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - pathology
Diagnosis, Differential
Granulomatosis with Polyangiitis - diagnosis
Granulomatosis with Polyangiitis - pathology
Humans
Male
Medical sciences
Middle Aged
Pancreas - diagnostic imaging
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 62-year-old male presented with painless jaundice and solitary pulmonary and pancreatic masses. An extensive evaluation revealed Wegener's granulomatosis as the etiology. His pancreatic mass and jaundice responded to temporary stenting and therapy with cyclophosphamide and prednisone. While pancreatic vasculitis in Wegener's granulomatosis has been noted previously in autopsy studies, symptomatic involvement has been reported only once previously and never as a presenting feature of the disease. The antineutrophil cytoplasmic antibody (ANCA) assay proved useful in establishing the diagnosis. Necrotizing vasculidities can mimic pancreatic carcinoma and should be considered in the differential diagnosis of atypical cases.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01296425