Comparative study on the application of capillary liquid chromatography and capillary electrochromatography for investigation of enantiomeric purity of the contraceptive drug levonorgestrel

In the last few years, it has been shown that capillary electrochromatography (CEC) is a promising technique for enantioseparations. However, to date almost no studies are published on a critical comparison of CEC and its pressure-driven counterpart, capillary liquid chromatography (CLC) for real sa...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2003-01, Vol.30 (6), p.1897-1906
Main Authors: Chankvetadze, Bezhan, Kartozia, Irma, Yamamoto, Chiyo, Okamoto, Yoshio, Blaschke, Gottfried
Format: Article
Language:English
Subjects:
Capillary electrochromatography
Capillary liquid chromatography
Chiral drugs
Chromatography, Liquid - methods
Chromatography, Micellar Electrokinetic Capillary - methods
Contraceptives, Oral, Synthetic - analysis
Contraceptives, Oral, Synthetic - chemistry
Drug Contamination
Enantiomeric impurity determination
Enantioseparation
Levonorgestrel
Levonorgestrel - analysis
Levonorgestrel - chemistry
Stereoisomerism
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Summary:In the last few years, it has been shown that capillary electrochromatography (CEC) is a promising technique for enantioseparations. However, to date almost no studies are published on a critical comparison of CEC and its pressure-driven counterpart, capillary liquid chromatography (CLC) for real samples. In this study, the goal was to compare CLC and CEC for the determination of the enantiomeric purity of the contraceptive drug levonorgestrel and its pharmaceutical formulation. The study prevailed that not all potential advantages of CEC over CLC can easily be transformed in a real gain of detection limit of the enantiomeric impurity. However, certain advantages of CEC over CLC have been unambiguously shown.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(02)00533-2