New perspectives on growth factor-sex steroid interaction in the prostate

Many organs respond to both sex steroids and growth factors. Regulation of these pathways is integral to cell–cell communications during development and aberrant changes cause disease pathogenesis. Traditionally, paracrine and endocrine actions of growth factors and steroid hormones are considered i...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2003-02, Vol.14 (1), p.5-16
Main Authors: Ball, Emma M.A, Risbridger, Gail P
Format: Article
Language:English
Subjects:
Activin
Activins - metabolism
Androgen
Cell Communication - physiology
Cross-talk
Estrogen
Female
Gonadal Steroid Hormones - metabolism
Growth Substances - metabolism
Humans
Male
Prostate - metabolism
Signal Transduction - physiology
TGFβ
Transforming Growth Factor beta - metabolism
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Summary:Many organs respond to both sex steroids and growth factors. Regulation of these pathways is integral to cell–cell communications during development and aberrant changes cause disease pathogenesis. Traditionally, paracrine and endocrine actions of growth factors and steroid hormones are considered independently. Recently, new data indicated that activin/TGFβ and sex steroid signalling are linked; explicitly, that the pathways cross-talk intracellularly. Here we present new perspectives on these interactions, using examples predominantly from the prostate, as it is a well-characterised organ in this context. While this information provides insight to the potential mechanisms behind these interactions, it also presents a new challenge; the action of any of these factors cannot be considered exclusively without considering the impact on the other biological pathways.
ISSN:1359-6101
DOI:10.1016/S1359-6101(02)00052-7