The CBF Threshold and Dynamics for Focal Cerebral Infarction in Spontaneously Hypertensive Rats

Two strategies were used to estimate the blood flow threshold for focal cerebral infarction in spontaneously hypertensive rats (SHRs) subjected to permanent middle cerebral artery and common carotid artery occlusion (MCA/CCAO). The first compared the volume of cortical infarction (24 h after ischemi...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1992-05, Vol.12 (3), p.359-370
Main Authors: Jacewicz, Michael, Tanabe, Jody, Pulsinelli, William A.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Biological and medical sciences
Blood Flow Velocity
Brain Ischemia - physiopathology
Cerebral Infarction - physiopathology
Cerebrovascular Circulation
Disease Models, Animal
Edema - physiopathology
Male
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Rats
Rats, Inbred SHR
Regional Blood Flow
Time Factors
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Summary:Two strategies were used to estimate the blood flow threshold for focal cerebral infarction in spontaneously hypertensive rats (SHRs) subjected to permanent middle cerebral artery and common carotid artery occlusion (MCA/CCAO). The first compared the volume of cortical infarction (24 h after ischemia onset) to the volumes of ischemic cortex (image analysis of [14C]iodoantipyrine CBF autoradiographs) perfused below CBF values
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1992.53