Tc-99m(V) DMSA Imaging: A New Approach to Studying Metastases from Breast Carcinoma

Combined Tc-99m MDP skeletal imaging and Tc-99m(V) DMSA whole body scans to detect metastates were performed during the follow-up of 30 patients who underwent surgery for breast carcinoma. Eight patients had normal Tc-99m MDP and Tc-99m(V) DMSA scans and were declared free of metastatic disease, fur...

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Bibliographic Details
Published in:Clinical nuclear medicine 1992-02, Vol.17 (2), p.119-122
Main Authors: KASHYAP, R, BABBAR, A, SAHAI, I, PRAKASH, R, SONI, N L, CHAUHAN, U P S
Format: Article
Language:English
Subjects:
Adult
Aged
Bone and Bones - diagnostic imaging
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Breast Neoplasms - pathology
Evaluation Studies as Topic
Female
Humans
Middle Aged
Organotechnetium Compounds
Radionuclide Imaging
Sensitivity and Specificity
Soft Tissue Neoplasms - diagnostic imaging
Soft Tissue Neoplasms - secondary
Succimer
Technetium Tc 99m Dimercaptosuccinic Acid
Technetium Tc 99m Medronate
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Summary:Combined Tc-99m MDP skeletal imaging and Tc-99m(V) DMSA whole body scans to detect metastates were performed during the follow-up of 30 patients who underwent surgery for breast carcinoma. Eight patients had normal Tc-99m MDP and Tc-99m(V) DMSA scans and were declared free of metastatic disease, further confirmed by no change in symptomatology over a 1-year follow-up period. Twenty-two patients had positive Tc- 99m MDP scans with varied skeletal involvement. Tc- 99m(V) DMSA scans showed matched areas of increased radiotracer concentration in bony metastases in 20 of these patients. Tc-99m(V) DMSA concentration was not seen in traumatic vertebral collapse or in coexistent osteoarthritic disease in vertebral metastatic involvement. Interestingly, Tc-99m(V) DMSA showed increased concentration in brain and liver metastases. Pentavalent Tc-99m(V) DMSA appears useful for detecting skeletal and soft-tissue metastases in breast carcinoma, and can improve the specificity of Tc-99m MDP bone scans in screening for bone metastases.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199202000-00011