Rapid screening for bacteriuria in pregnancy

We evaluated a bioluminescence assay as a screening test for the detection of bacteriuria in pregnancy. A total of 1,000 urine specimens from a randomly selected group of pregnant women undergoing prenatal surveillance was investigated. Sequential dilution of urine specimens on CLED agar plates serv...

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Bibliographic Details
Published in:Infection 1992, Vol.20 (1), p.9-11
Main Authors: GRANINGER, W, FLEISCHMANN, D, SCHNEWEISS, B, ARAM, L, STOCKENHUBER, F
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Bacteriological methods and techniques used in bacteriology
Bacteriology
Bacteriuria - prevention & control
Bacteriuria - urine
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Humans
Luminescent Measurements
Mass Screening - methods
Microbiology
Pregnancy
Pregnancy Complications, Infectious - prevention & control
Pregnancy Complications, Infectious - urine
Sensitivity and Specificity
Time Factors
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Summary:We evaluated a bioluminescence assay as a screening test for the detection of bacteriuria in pregnancy. A total of 1,000 urine specimens from a randomly selected group of pregnant women undergoing prenatal surveillance was investigated. Sequential dilution of urine specimens on CLED agar plates served as a reference method. Set against the reference group, bioluminescence screening scored a 93% sensitivity, a 78% specificity and a 99% predictive accuracy for negative results. All urine specimens were also analysed chemically for the presence of nitrite and leucocyte esterase by dip sticks. Dip sticks proved to be insufficient because of poor sensitivities of 54% and 59%, respectively. The bioluminescence assay is an effective, time- as well as labor-saving but questionably cost-effective method for the detection of bacteriuria in pregnancy.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01704885