Granulomas in schistosome and mycobacterial infections: a model of local immune responses

Granulomatous immune responses are interesting models for the effector phase of immunity, in that granulomas can be part of both immune protection and disease pathology during the course of various infectious and autoimmune diseases. Focusing mainly on granulomas induced by Schistosoma or Mycobacter...

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Bibliographic Details
Published in:Trends in immunology 2003, Vol.24 (1), p.44-52
Main Authors: Sandor, Matyas, Weinstock, Joel V., Wynn, Thomas A.
Format: Article
Language:English
Subjects:
Animals
Cytokines - metabolism
Granuloma - immunology
Granuloma - pathology
Humans
Macrophages - immunology
Mycobacterium Infections - immunology
Mycobacterium Infections - pathology
Neuropeptides - metabolism
Schistosomiasis - immunology
Schistosomiasis - pathology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Granulomatous immune responses are interesting models for the effector phase of immunity, in that granulomas can be part of both immune protection and disease pathology during the course of various infectious and autoimmune diseases. Focusing mainly on granulomas induced by Schistosoma or Mycobacterium infection, this article reviews T-cell recruitment, local cytokine networks and the regulation of cytokine networks by neuropeptides in granulomas. In addition, different activation pathways for macrophages residing in granulomas are discussed. Granulomas are unique inflammatory sites that offer a challenging and rewarding model to study immunity.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(02)00006-6