Structural and mechanical basis of exercise-induced muscle injury

It is well documented in both animal and human studies that unaccustomed, particularly eccentric, muscle exercise may cause damage of muscle fiber contractile and cytoskeletal components. These injuries typically include: Z-band streaming and dissolution, A-band disruption, disintegration of the int...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 1992-05, Vol.24 (5), p.521-530
Main Authors: Fridén, J, Lieber, R L
Format: Article
Language:English
Subjects:
Animals
Cytoskeleton - ultrastructure
Exercise - physiology
Humans
Muscle Contraction
Muscles - pathology
Myofibrils - ultrastructure
Oxygen Consumption - physiology
Physical Exertion - physiology
Sarcomeres - pathology
Space life sciences
Time Factors
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Summary:It is well documented in both animal and human studies that unaccustomed, particularly eccentric, muscle exercise may cause damage of muscle fiber contractile and cytoskeletal components. These injuries typically include: Z-band streaming and dissolution, A-band disruption, disintegration of the intermediate filament system, and misalignment of the myofibrils. The mechanical basis for this damage is suggested to be due to the fiber strain magnitude rather than the absolute stress imposed on the fiber. We hypothesize that eccentric contraction-induced damage occurs early in the treatment period, i.e., within the first few minutes. The structural abnormalities predominate in the fast-twitch glycolytic fibers. In the final section of this paper, we hypothesize a damage scheme, based on the muscle fiber oxidative capacity as a determining factor.
ISSN:0195-9131
DOI:10.1249/00005768-199205000-00005