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Interleukin-8 in Cord Sera: A Sensitive and Specific Marker for the Detection of Preterm Chorioamnionitis

Interleukin-8 (IL-8) exerts chemotactic activity on neutrophils at inflammatory sites to eliminate invading bacteria. To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) u...

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Published in:	The Journal of infectious diseases 1992-05, Vol.165 (5), p.957-960
Main Authors:	Shimoya, Kouichirou, Matsuzaki, Noboru, Taniguchi, Takeshi, Jo, Toushun, Saji, Fumitaka, Kitajima, Hiroyuki, Fujimura, Masanori, Nakayama, Masahiro, Tanizawa, Osamu
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - therapeutic use Bacteria Betamethasone - pharmacology Betamethasone - therapeutic use Chorioamnionitis Chorioamnionitis - diagnosis Chorioamnionitis - etiology Concise Communications Endotoxins Female Fetal Blood - immunology Fetal Membranes, Premature Rupture - complications Fetal Organ Maturity - drug effects Fetus Histology Humans Infant, Newborn Infants Interleukin-8 - blood Leukocytes Lung - drug effects Lung - embryology Neutrophils Obstetric Labor, Premature - complications Pregnancy Retrospective Studies Sensitivity and Specificity Steroids Titration
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cited_by	cdi_FETCH-LOGICAL-c385t-e270b97395232fc4a86f03856c1cd8ea0e8d49b308e04560264823363ce73ee13
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container_title	The Journal of infectious diseases
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creator	Shimoya, Kouichirou Matsuzaki, Noboru Taniguchi, Takeshi Jo, Toushun Saji, Fumitaka Kitajima, Hiroyuki Fujimura, Masanori Nakayama, Masahiro Tanizawa, Osamu
description	Interleukin-8 (IL-8) exerts chemotactic activity on neutrophils at inflammatory sites to eliminate invading bacteria. To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) using an EIA kit specific for IL-8. The infected babies had a significantly higher IL-8 titer than those not infected at 22–36 gestational weeks. The IL-8 titer was increased even in the mild histologic stage of chorioamnionitis and became much higher in the more severe stage. The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation. This retrospective study demonstrated that titration of IL-8 in cord serum is a more useful marker for the early detection of chorioamnionitis, because of its higher sensitivity and specificity, than conventional markers such as C-reactive protein.
doi_str_mv	10.1093/infdis/165.5.957
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To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) using an EIA kit specific for IL-8. The infected babies had a significantly higher IL-8 titer than those not infected at 22–36 gestational weeks. The IL-8 titer was increased even in the mild histologic stage of chorioamnionitis and became much higher in the more severe stage. The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation. This retrospective study demonstrated that titration of IL-8 in cord serum is a more useful marker for the early detection of chorioamnionitis, because of its higher sensitivity and specificity, than conventional markers such as C-reactive protein.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/165.5.957</identifier><identifier>PMID: 1569349</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bacteria ; Betamethasone - pharmacology ; Betamethasone - therapeutic use ; Chorioamnionitis ; Chorioamnionitis - diagnosis ; Chorioamnionitis - etiology ; Concise Communications ; Endotoxins ; Female ; Fetal Blood - immunology ; Fetal Membranes, Premature Rupture - complications ; Fetal Organ Maturity - drug effects ; Fetus ; Histology ; Humans ; Infant, Newborn ; Infants ; Interleukin-8 - blood ; Leukocytes ; Lung - drug effects ; Lung - embryology ; Neutrophils ; Obstetric Labor, Premature - complications ; Pregnancy ; Retrospective Studies ; Sensitivity and Specificity ; Steroids ; Titration</subject><ispartof>The Journal of infectious diseases, 1992-05, Vol.165 (5), p.957-960</ispartof><rights>Copyright 1992 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-e270b97395232fc4a86f03856c1cd8ea0e8d49b308e04560264823363ce73ee13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1569349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimoya, Kouichirou</creatorcontrib><creatorcontrib>Matsuzaki, Noboru</creatorcontrib><creatorcontrib>Taniguchi, Takeshi</creatorcontrib><creatorcontrib>Jo, Toushun</creatorcontrib><creatorcontrib>Saji, Fumitaka</creatorcontrib><creatorcontrib>Kitajima, Hiroyuki</creatorcontrib><creatorcontrib>Fujimura, Masanori</creatorcontrib><creatorcontrib>Nakayama, Masahiro</creatorcontrib><creatorcontrib>Tanizawa, Osamu</creatorcontrib><title>Interleukin-8 in Cord Sera: A Sensitive and Specific Marker for the Detection of Preterm Chorioamnionitis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Interleukin-8 (IL-8) exerts chemotactic activity on neutrophils at inflammatory sites to eliminate invading bacteria. To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) using an EIA kit specific for IL-8. The infected babies had a significantly higher IL-8 titer than those not infected at 22–36 gestational weeks. The IL-8 titer was increased even in the mild histologic stage of chorioamnionitis and became much higher in the more severe stage. The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation. 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Matsuzaki, Noboru ; Taniguchi, Takeshi ; Jo, Toushun ; Saji, Fumitaka ; Kitajima, Hiroyuki ; Fujimura, Masanori ; Nakayama, Masahiro ; Tanizawa, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-e270b97395232fc4a86f03856c1cd8ea0e8d49b308e04560264823363ce73ee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteria</topic><topic>Betamethasone - pharmacology</topic><topic>Betamethasone - therapeutic use</topic><topic>Chorioamnionitis</topic><topic>Chorioamnionitis - diagnosis</topic><topic>Chorioamnionitis - etiology</topic><topic>Concise Communications</topic><topic>Endotoxins</topic><topic>Female</topic><topic>Fetal Blood - immunology</topic><topic>Fetal Membranes, Premature Rupture - complications</topic><topic>Fetal Organ Maturity - drug effects</topic><topic>Fetus</topic><topic>Histology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Interleukin-8 - blood</topic><topic>Leukocytes</topic><topic>Lung - drug effects</topic><topic>Lung - embryology</topic><topic>Neutrophils</topic><topic>Obstetric Labor, Premature - complications</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Steroids</topic><topic>Titration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimoya, Kouichirou</creatorcontrib><creatorcontrib>Matsuzaki, Noboru</creatorcontrib><creatorcontrib>Taniguchi, Takeshi</creatorcontrib><creatorcontrib>Jo, Toushun</creatorcontrib><creatorcontrib>Saji, Fumitaka</creatorcontrib><creatorcontrib>Kitajima, Hiroyuki</creatorcontrib><creatorcontrib>Fujimura, Masanori</creatorcontrib><creatorcontrib>Nakayama, Masahiro</creatorcontrib><creatorcontrib>Tanizawa, Osamu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimoya, Kouichirou</au><au>Matsuzaki, Noboru</au><au>Taniguchi, Takeshi</au><au>Jo, Toushun</au><au>Saji, Fumitaka</au><au>Kitajima, Hiroyuki</au><au>Fujimura, Masanori</au><au>Nakayama, Masahiro</au><au>Tanizawa, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-8 in Cord Sera: A Sensitive and Specific Marker for the Detection of Preterm Chorioamnionitis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>165</volume><issue>5</issue><spage>957</spage><epage>960</epage><pages>957-960</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Interleukin-8 (IL-8) exerts chemotactic activity on neutrophils at inflammatory sites to eliminate invading bacteria. To investigate whether the preterm fetus with chorioamnionitis produces IL-8, the titers of IL-8 were examined in sera of babies with (n = 38) and without chorioamnionitis (n = 34) using an EIA kit specific for IL-8. The infected babies had a significantly higher IL-8 titer than those not infected at 22–36 gestational weeks. The IL-8 titer was increased even in the mild histologic stage of chorioamnionitis and became much higher in the more severe stage. The IL-8 elevation, however, was remarkably suppressed by infusion of a steroid into the mother to promote fetal lung maturation. 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source	Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects	Anti-Bacterial Agents - therapeutic use Bacteria Betamethasone - pharmacology Betamethasone - therapeutic use Chorioamnionitis Chorioamnionitis - diagnosis Chorioamnionitis - etiology Concise Communications Endotoxins Female Fetal Blood - immunology Fetal Membranes, Premature Rupture - complications Fetal Organ Maturity - drug effects Fetus Histology Humans Infant, Newborn Infants Interleukin-8 - blood Leukocytes Lung - drug effects Lung - embryology Neutrophils Obstetric Labor, Premature - complications Pregnancy Retrospective Studies Sensitivity and Specificity Steroids Titration
title	Interleukin-8 in Cord Sera: A Sensitive and Specific Marker for the Detection of Preterm Chorioamnionitis
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