Elevated glial brain-derived neurotrophic factor in Parkinson's diseased nigra

We show the cellular distribution of immunoreactivity (IR) for brain-derived-neurotrophic-factor (BDNF), neurotrophin-3 (NT-3) and tyrosine kinase receptors TRKB and TRKC in idiopathic Parkinson's disease (IPD) and controls at post-mortem. In both groups, nigral neurons, astrocytes, ramified an...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2002-06, Vol.8 (5), p.329-341
Main Authors: Knott, C, Stern, G, Kingsbury, A, Welcher, A.A, Wilkin, G.P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Astrocytes
Astrocytes - metabolism
Astrocytes - pathology
Brain-Derived Neurotrophic Factor - metabolism
Female
human
Humans
Immunohistochemistry
Male
Microglia
Microglia - metabolism
Microglia - pathology
Middle Aged
Neostriatum - metabolism
Neostriatum - pathology
Neurons - metabolism
Neurons - pathology
Neurotrophin 3 - metabolism
Neurotrophins
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
Receptor, trkB - metabolism
Receptor, trkC - metabolism
Substantia Nigra - metabolism
Substantia Nigra - pathology
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Summary:We show the cellular distribution of immunoreactivity (IR) for brain-derived-neurotrophic-factor (BDNF), neurotrophin-3 (NT-3) and tyrosine kinase receptors TRKB and TRKC in idiopathic Parkinson's disease (IPD) and controls at post-mortem. In both groups, nigral neurons, astrocytes, ramified and amoeboid microglia expressed all antigens. Caudate-putamen neurons expressed all antigens except BDNF with similar distribution between groups. In IPD nigra, increased numbers of BDNF-IR and, less frequently, NT-3-IR ramified glia surrounded fragmented neurons, accompanied by BDNF-IR in surrounding neuropil. Amoeboid microglia were abundant only in IPD nigral scars. In IPD, glia might up-regulate neurotrophins in response to signals released from failing nigral neurons.
ISSN:1353-8020
1873-5126
DOI:10.1016/S1353-8020(02)00008-1