Non-immunological release of histamine from rat mast cells elicited by antineoplastic agents

We studied the histamine-releasing activity of several antineoplastic drugs on rat pleural and peritoneal mast cells. The drugs tested included the nitrogen mustards cyclophosphamide and ifosfamide, the nitrosourea carmustine, the triazene dacarbazine, the folic acid analogue methotrexate, the pyrim...

Full description

Saved in:
Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1992, Vol.29 (6), p.495-498
Main Authors: BOTANA, L. M, ARNAEZ, E, VIEYTES, M. R, ALFONSO, A, BUJAN, M. J, LOUZAO, M. C, CABADO, A
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cells, Cultured
Drug toxicity and drugs side effects treatment
Histamine Release - drug effects
Mast Cells - drug effects
Mast Cells - metabolism
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Peritoneal Cavity - cytology
Pharmacology. Drug treatments
Pleura - cytology
Rats
Rats, Inbred Strains
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the histamine-releasing activity of several antineoplastic drugs on rat pleural and peritoneal mast cells. The drugs tested included the nitrogen mustards cyclophosphamide and ifosfamide, the nitrosourea carmustine, the triazene dacarbazine, the folic acid analogue methotrexate, the pyrimidine analogue cytarabine and fluorouracil, the vinca alkaloids vinblastine, vincristine and Vinorelbine, the epipodophyllotoxins etoposide and teniposide, and the enzyme L-asparaginase. Methotrexate, carmustine, fluorouracil, vinblastine and vincristine failed to elicit histamine release on rat mast cells. All of the other drugs evoked histamine release in both the presence and the absence of extracellular calcium, but ifosfamide, cytarabine and asparaginase induced a much lower release in the absence of this cation. The response elicited by cytarabine and etoposide was much higher in pleural than in peritoneal mast cells. These results indicate that some antineoplastic drugs may directly activate the release of histamine, which could contribute to some of their secondary effects.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00684855