Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo

The efficacy of sodium valproate (Depalept) versus placebo in the treatment of migraine was evaluated in a double-blind randomized cross-over study in twenty-nine patients. The patients were divided into two groups each of which was alternately given 400 mg of sodium valproate B.I.d or placebo for e...

Full description

Saved in:
Bibliographic Details
Published in:Cephalalgia 1992-04, Vol.12 (2), p.81-84
Main Authors: Hering, R, Kuritzky, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Circadian rhythm
Depalept
Double-Blind Method
Female
Humans
Male
Medical sciences
Middle Aged
migraine
Migraine Disorders - physiopathology
Migraine Disorders - prevention & control
Neurology
sodium valproate
Valproic Acid - blood
Valproic Acid - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The efficacy of sodium valproate (Depalept) versus placebo in the treatment of migraine was evaluated in a double-blind randomized cross-over study in twenty-nine patients. The patients were divided into two groups each of which was alternately given 400 mg of sodium valproate B.I.d or placebo for eight weeks and then crossed over for an additional eight weeks. Our results show that in 86.2% of the patients sodium valproate was effective in preventing migraine or reducing the frequency, severity and duration of the attacks. In general, the drug was well tolerated and proved to be an effective treatment in migraine.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1992.1202081.x