Three novel single nucleotide polymorphisms in UGT1A10

Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A10 gene from 24 Japanese patients with various cancers who were administered the anti-tumor drug, irinotecan (CPT-II). The detected SNPs were as follows:1)SNP, MPJ6_U1A003; GENE NAME, UGT1A10; AC...

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Published in:Drug metabolism and pharmacokinetics 2002, Vol.17 (5), p.488-490
Main Authors: Saeki, Mayumi, Ozawa, Shogo, Saito, Yoshiro, Jinno, Hideto, Hamaguchi, Tetsuya, Nokihara, Hiroshi, Shimada, Yasuhiro, Kunitoh, Hideo, Yamamoto, Noboru, Ohe, Yuichiro, Yamada, Yasuhide, Shirao, Kuniaki, Muto, Manabu, Mera, Kiyomi, Goto, Koichi, Ohmatsu, Hironobu, Kubota, Kaoru, Niho, Seiji, Kakinuma, Ryutaro, Minami, Hironobu, Ohtsu, Atsushi, Yoshida, Teruhiko, Saijo, Nagahiro, Sawada, Jun-ichi
Format: Article
Language:English
Subjects:
amino acid alteration
drug metabolism
novel SNP
UGTIAIO
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Summary:Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A10 gene from 24 Japanese patients with various cancers who were administered the anti-tumor drug, irinotecan (CPT-II). The detected SNPs were as follows:1)SNP, MPJ6_U1A003; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CAGATGCCATGAC/TTTTCAAGGAGAG-3'2)SNP, MPJ6_U1A004; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CCTAGAAATAGCC/TTCTGAAATTCTC-3'3)SNP, MPJ6_U1A030; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-GGTTGTAGTCATG/ACCAGAGGTGAGT-3' All the three SNPs were located in exon 1 and their frequencies were all 0.021. Among these SNPs, MPJ6_U1A003 and U1A030 resulted in amino acid alterations, T202I and M59I, respectively. The third SNP, MPJ6_U1A004, introduced a synonymous amino acid change (A231A).
ISSN:1347-4367
1880-0920
DOI:10.2133/dmpk.17.488