apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins

The apterous (ap) gene is required for the normal development of the wing and haltere imaginal discs in Drosophila melanogaster. ap encodes a new member of the LIM family of developmental regulatory genes. The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich do...

Full description

Saved in:
Bibliographic Details
Published in:Genes & development 1992-05, Vol.6 (5), p.715-729
Main Authors: COHEN, B, MCGUFFIN, M. E, PFEIFLE, C, SEGAL, D, COHEN, S. M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
apterous gene
Base Sequence
Biological and medical sciences
Cell Differentiation - genetics
Cloning, Molecular
development
DNA Transposable Elements - genetics
Drosophila melanogaster
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila Proteins
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - genetics
genes
Genes, Homeobox - genetics
Genes. Genome
Homeodomain Proteins
imaginal discs
LIM-Homeodomain Proteins
Male
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Mutation - genetics
nucleotide sequence
predictions
products
role
Transcription Factors - chemistry
Transcription Factors - genetics
Wings, Animal - embryology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The apterous (ap) gene is required for the normal development of the wing and haltere imaginal discs in Drosophila melanogaster. ap encodes a new member of the LIM family of developmental regulatory genes. The deduced amino acid sequence of ap predicts a homeo domain and a cysteine/histidine-rich domain known as the LIM domain. In these domains ap is highly similar to the mec-3 and lin-11 proteins of Caenorhabditis elegans and to the vertebrate insulin enhancer-binding protein isl-1. ap is presumably required for transcriptional regulation of genes involved in wing and haltere development. The nature of the defects in homozygous null mutant flies is consistent with the pattern of ap expression in the larval imaginal discs. ap is also expressed in a complex pattern in the embryo, including portions of the peripheral nervous system (PNS) and central nervous system (CNS). A requirement for ap expression in the larval and adult CNS may be the underlying cause of the defects in hormone production and vitellogenesis described for ap mutations.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.6.5.715