Relation Between Glycolysis and Calcium Homeostasis in Postischemic Myocardium

This study examined the hypothesis that glycolysis is required for functional recovery of the myocardium during reperfusion by facilitating restoration of calcium homeostasis. [Ca]i was measured in isolated perfused rabbit hearts by using the Ca indicator 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N...

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Bibliographic Details
Published in:Circulation research 1992-06, Vol.70 (6), p.1180-1190
Main Authors: Jeremy, Richmond W, Koretsune, Yukihiro, Marban, Eduardo, Becker, Lewis C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - metabolism
Female
Fundamental and applied biological sciences. Psychology
Glycolysis
Heart
Homeostasis
Magnetic Resonance Spectroscopy
Models, Cardiovascular
Myocardial Reperfusion Injury - metabolism
Myocardium - metabolism
Pyruvates - metabolism
Rabbits
Time Factors
Vertebrates: cardiovascular system
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Summary:This study examined the hypothesis that glycolysis is required for functional recovery of the myocardium during reperfusion by facilitating restoration of calcium homeostasis. [Ca]i was measured in isolated perfused rabbit hearts by using the Ca indicator 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,Nʼ,Nʼ-tetraacetic acid (5F-BAPTA) and F nuclear magnetic resonance spectroscopy. In nonischemic control hearts, inhibition of glycolysis with iodoacetate did not alter [Ca]i. In hearts subjected to 20 minutes of global zero-flow ischemia, [Ca]i increased from 260±80 nM before ischemia to 556±44 nM after 15 minutes of ischemia (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.70.6.1180