Meningoencephalitis due to penicillin-resistant Streptococcus pneumoniae

The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory leve...

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Bibliographic Details
Published in:Intensive care medicine 1992-01, Vol.18 (1), p.56-58
Main Authors: VASSAL, T, PIOT, O, MALLAT, Z, LESAGE, D, GUIDET, B, OFFENSTADT, G
Format: Article
Language:English
Subjects:
Aged
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cefotaxime - administration & dosage
Cefotaxime - cerebrospinal fluid
Cefotaxime - therapeutic use
Humans
Male
Medical sciences
Meningoencephalitis - cerebrospinal fluid
Meningoencephalitis - drug therapy
Meningoencephalitis - microbiology
Microbial Sensitivity Tests
Penicillin Resistance
Pharmacology. Drug treatments
Pneumococcal Infections - cerebrospinal fluid
Pneumococcal Infections - drug therapy
Pneumococcal Infections - microbiology
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Summary:The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory level of antibiotic in the cerebrospinal fluid with moderate dosage. In France, as well as in many countries, high doses of third-generation cephalosporins such as cefotaxime or ceftriaxone should be administered for the initial therapy of suspected pneumococcal meningitis.
ISSN:0342-4642
1432-1238
DOI:10.1007/BF01706430