A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY: II. THE STRUCTURAL ELUCIDATION OF SF2575

The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1992/03/25, Vol.45(3), pp.325-330
Main Authors: HATSU, MASAHIRO, SASAKI, TORU, GOMI, SHUICHI, KODAMA, YOSHIO, SEZAKI, MASAJI, INOUYE, SHIGEHARU, KONDO, SHINICHI
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Molecular Conformation
Streptomyces
Tetracyclines - chemistry
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicylic acid and angelic acid moieties.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.325