Inhibition of cell migration from tendon explants into fibrin clots by extracts derived from cheese whey is largely due to transforming growth factor-beta

Whey-derived growth factor extract (WGFE) and the acid-activated form (WGFE-a) were tested for their ability to influence the migration of cells from chicken flexor tendon biopsies into fibrin clots. When added to the medium surrounding clots, both extracts significantly inhibited migration relative...

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Bibliographic Details
Published in:Journal of orthopaedic research 2003, Vol.21 (1), p.157-161
Main Authors: Conlon, Michael A, Tomas, Frank M
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacology
Cell migration
Cell Movement - drug effects
Cheese
Chickens
Fibrin - pharmacology
Milk Proteins - pharmacology
Tendon
Tendons - cytology
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta2
Transforming growth factor- β
Whey
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Summary:Whey-derived growth factor extract (WGFE) and the acid-activated form (WGFE-a) were tested for their ability to influence the migration of cells from chicken flexor tendon biopsies into fibrin clots. When added to the medium surrounding clots, both extracts significantly inhibited migration relative to controls ( P
ISSN:0736-0266
1554-527X
DOI:10.1016/S0736-0266(02)00096-7