Selective Complexation of N-Alkylpyridinium Salts: Recognition of NAD+ in Water

A molecular clip made of two naphthalene side walls and bisphosphonate arms selectively binds to N‐alkylpyridinium ions in water. Through the unique potential of this clip to combine π–cation and electrostatic interactions with the hydrophobic effect, the host molecule is able to complex NAD+ (nicot...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-04, Vol.41 (8), p.1355-1358
Main Authors: Jasper, Christian, Schrader, Thomas, Panitzky, Jens, Klärner, Frank-Gerrit
Format: Article
Language:English
Subjects:
molecular clips
molecular recognition
N-alkylpyridinium salts
NAD
noncovalent interactions
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Description
Summary:A molecular clip made of two naphthalene side walls and bisphosphonate arms selectively binds to N‐alkylpyridinium ions in water. Through the unique potential of this clip to combine π–cation and electrostatic interactions with the hydrophobic effect, the host molecule is able to complex NAD+ (nicotinamide adenine dinucleotide; see picture) efficiently in aqueous solution.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020415)41:8<1355::AID-ANIE1355>3.0.CO;2-6