Colorimetric and Fluorometric Detection of Nucleic Acids Using Cationic Polythiophene Derivatives

Different electrostatic interactions and conformational structures between single‐ or double‐stranded negatively charged nucleic acids bound to a surface (see picture) and water‐soluble cationic poly(3‐alkoxy‐4‐methylthiophene) derivatives (in yellow) provide the basis for a sensitive optical detect...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2002-05, Vol.41 (9), p.1548-1551
Main Authors: Ho, Hoang-Anh, Boissinot, Maurice, Bergeron, Michel G., Corbeil, Geneviève, Doré, Kim, Boudreau, Denis, Leclerc, Mario
Format: Article
Language:English
Subjects:
Cationic
Charging
Colorimetry
Colorimetry - economics
Colorimetry - methods
conducting materials
Derivatives
DNA recognition
electrostatic interactions
Electrostatics
fluorescence
Fluorometers
Nucleic acids
Nucleic Acids - analysis
Oligonucleotides
Polymers - chemistry
Sensitivity and Specificity
sensors
Spectrometry, Fluorescence - economics
Spectrometry, Fluorescence - methods
Thiophenes - chemistry
Time Factors
Citations: Items that this one cites
Online Access:Get full text
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Description
Summary:Different electrostatic interactions and conformational structures between single‐ or double‐stranded negatively charged nucleic acids bound to a surface (see picture) and water‐soluble cationic poly(3‐alkoxy‐4‐methylthiophene) derivatives (in yellow) provide the basis for a sensitive optical detection method (colorimetric or fluorometric) for oligonucleotide hybridization.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020503)41:9<1548::AID-ANIE1548>3.0.CO;2-I