Characterization of autofluorescence in oral squamous cell carcinoma

This study was carried out to evaluate the clinical characteristics of autofluorescence in oral squamous cell carcinoma (SCC) and analyze the fluorescent substances using high-performance liquid chromatography (HPLC). Fifty of 55 oral SCCs (91%) emitted orange or red fluorescence, which was recorded...

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Bibliographic Details
Published in:Oral oncology 2003-02, Vol.39 (2), p.150-156
Main Authors: Onizawa, Kojiro, Okamura, Naomichi, Saginoya, Hideo, Yoshida, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Autofluorescence
Biological and medical sciences
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - pathology
Chromatography, High Pressure Liquid - methods
Coproporphyrins - analysis
Disease Progression
Ent. Stomatology
Female
Fluorescence
HPLC
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Mouth Neoplasms - chemistry
Mouth Neoplasms - pathology
Oral cancer
Otorhinolaryngology. Stomatology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Photography
Porphyrin
Porphyrins - analysis
Protoporphyrin IX
Protoporphyrins - analysis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:This study was carried out to evaluate the clinical characteristics of autofluorescence in oral squamous cell carcinoma (SCC) and analyze the fluorescent substances using high-performance liquid chromatography (HPLC). Fifty of 55 oral SCCs (91%) emitted orange or red fluorescence, which was recorded by fluorescence photography. The intensity of the fluorescence significantly correlated with the T and N categories of the cancers, but did not show statistical difference for the types of clinical appearance and primary sites. Protoporphyrin and coproporphyrin were identified as the fluorescent substance in the SCC samples, and the elution patterns on HPLC revealed some porphyrin compounds as specific to oral cancer. These results suggest that the autofluorescence in oral SCC correlates with the progression of lesions, and that fluorescent substances such as protoporphyrin are produced in association with the cancerous tissue.
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(02)00036-2