Effect of Berberine on Bone Mineral Density in SAMP6 as a Senile Osteoporosis Model

The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentr...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2003, Vol.26(1), pp.110-111
Main Authors: Li, Huiying, Miyahara, Tatsuro, Tezuka, Yasuhiro, Tran, Quan Le, Seto, Hikaru, Kadota, Shigetoshi
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - genetics
Aging - metabolism
Animals
berberine
Berberine - chemistry
Berberine - pharmacology
Berberine - therapeutic use
Biological and medical sciences
Bone Density - drug effects
Bone Density - physiology
bone mineral density (BMD)
deoxypyridinoline (Dpd)
Disease Models, Animal
Female
Hydrastis - chemistry
Male
Medical sciences
Mice
Mice, Mutant Strains
Osteoporosis - drug therapy
Osteoporosis - genetics
Osteoporosis - metabolism
procollagen type I carboxyterminal extension peptide (PICP)
Ranunculaceae - chemistry
senescence accelerated mice P6 (SAMP6)
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Summary:The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.26.110