Treatment of membranoproliferative glomerulonephritis and nephrotic syndrome in a dog with a thromboxane synthetase inhibitor

A 2-year-old spayed female Whippet with membranoproliferative glomerulonephritis and nephrotic syndrome was treated with a specific thromboxane synthetase inhibitor (3-methyl-2[3-pyridyl]-1-indoleoctanoic acid), resulting in decreased proteinuria and resolution of ascites and edema. Glomerular histo...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1992-03, Vol.6 (2), p.77-81
Main Authors: Grauer, G.F. (Colorado State University), Frisbie, D.D, Snyder, P.S, Dubielzig, R.R, Panciera, D.L
Format: Article
Language:English
Subjects:
Animals
CASE REPORTS
CHIEN
Dog Diseases - drug therapy
DOGS
Female
GLOMERULONEFRITIS
GLOMERULONEPHRITE
GLOMERULONEPHRITIS
Glomerulonephritis, Membranoproliferative - drug therapy
Glomerulonephritis, Membranoproliferative - veterinary
Kidney Glomerulus - pathology
Kidney Glomerulus - ultrastructure
KIDNEYS
Microscopy, Electron
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - veterinary
PERRO
Pyridines - therapeutic use
REIN
RINONES
Thromboxane-A Synthase - antagonists & inhibitors
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Summary:A 2-year-old spayed female Whippet with membranoproliferative glomerulonephritis and nephrotic syndrome was treated with a specific thromboxane synthetase inhibitor (3-methyl-2[3-pyridyl]-1-indoleoctanoic acid), resulting in decreased proteinuria and resolution of ascites and edema. Glomerular histology, however, appeared unaffected by treatment. Discontinuation of treatment for 10 weeks resulted in increased proteinuria and decreased serum albumin concentrations that were again attenuated when treatment was reinitiated. Thromboxane synthetase inhibitors have been used successfully to treat experimentally induced glomerulonephritis in several species and this treatment appears to hold promise for naturally occurring glomerulonephritis in dogs.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1992.tb03155.x