Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification

Many studies profiling gene expression in human cancers have been completed and are in progress. Some studies (19-22) attempt to build predictors of patient prognosis and response to therapy by using gene expression profiles. Because it is likely that gene expression profiles will provide informatio...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2003-01, Vol.95 (1), p.14-18
Main Authors: Simon, Richard, Radmacher, Michael D., Dobbin, Kevin, McShane, Lisa M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cluster Analysis
Confounding Factors (Epidemiology)
Deoxyribonucleic acid
Diagnosis, Differential
Diagnostics
DNA
DNA, Neoplasm - analysis
Humans
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - diagnosis
Neoplasms - genetics
Oligonucleotide Array Sequence Analysis
Predictive Value of Tests
Prognosis
Reproducibility of Results
Research Design
Statistical analysis
Tumors
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Summary:Many studies profiling gene expression in human cancers have been completed and are in progress. Some studies (19-22) attempt to build predictors of patient prognosis and response to therapy by using gene expression profiles. Because it is likely that gene expression profiles will provide information that will affect clinical decision making, such profiling studies must be performed with statistical rigor and be reported clearly and with unbiased statistics.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/95.1.14