Hemodialysis infection prevention with polysporin ointment

• Published in: Journal of the American Society of Nephrology 2003, Vol.14 (1), p.169-179
• Main Authors: LOK, Charmaine E, STANLEY, Kenneth E, HUX, Janet E, RICHARDSON, Robert, TOBE, Sheldon W, CONLY, John
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Bacitracin - administration & dosage; Bacteremia - epidemiology; Bacterial Infections - etiology; Bacterial Infections - mortality; Bacterial Infections - prevention & control; Biological and medical sciences; Catheters, Indwelling - adverse effects; Double-Blind Method; Drug Combinations; Drug Therapy, Combination - administration & dosage; Emergency and intensive care: renal failure. Dialysis management; Female; Humans; Incidence; Infection Control - methods; Intensive care medicine; Male; Medical sciences; Middle Aged; Neomycin - administration & dosage; Ointments; Polymyxin B - administration & dosage; Prevalence; Renal Dialysis - adverse effects; Staphylococcal Infections - epidemiology; Survival Analysis
• ISSN: 1046-6673; 1533-3450
• DOI: 10.1097/01.ASN.0000038688.76195.A4

Hemodialysis patients in whom permanent vascular access cannot be achieved are dependent on a central venous catheter. In such patients, catheter-related infections are a common and serious complication. This study was a randomized clinical trial to determine if topical Polysporin Triple antibiotic ointment applied to the central venous catheter insertion site could reduce the incidence of catheter-related infections. A total of 169 patients receiving hemodialysis through a central venous catheter were randomized to receive Polysporin Triple or placebo using a double-blind study design. In the 6-mo study period, infections were observed in more patients in the placebo group than in the Polysporin Triple group (34 versus 12%; relative risk, 0.35; 95% CI, 0.18 to 0.68; P = 0.0013). The number of infections per 1000 catheter days (4.10 versus 1.02; P < 0.0001) and the number of bacteremias per 1000 catheter days (2.48 versus 0.63; P = 0.0004) were also greater in the placebo group. Within the 6-mo study period, there were 13 deaths in the placebo group as compared with 3 deaths in the Polysporin Triple group (P = 0.0041). When all available follow-up information was included, the difference in survival remained significant (19 versus 9 deaths; P = 0.0027). Within the first 6 mo, infections were observed in 7 of the 13 placebo subjects who died (54%) as compared with no infections in the three Polysporin Triple subjects who died. The prophylactic application of topical Polysporin Triple antibiotic ointment to the central venous catheter insertion site reduced the rate of infections and was associated with improved survival in hemodialysis patients.