Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex of Guam: Changing Incidence Rates during the Past 60 Years

In the 1950s, the incidence of amyotrophic lateral sclerosis (ALS, or Lytico) and parkinsonism-dementia complex (PDC, or Bodig) on the island of Guam was much higher than anywhere else in the world. From the late 1960s to the early 1980s, the incidence of both disorders has decreased. The objective...

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Bibliographic Details
Published in:American journal of epidemiology 2003-01, Vol.157 (2), p.149-157
Main Authors: Plato, Chris C., Garruto, Ralph M., Galasko, Douglas, Craig, Ulla-Katrina, Plato, Meropi, Gamst, Anthony, Torres, Jose M., Wiederholt, Wigbert
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
ALS
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - epidemiology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
dementia
Dementia - complications
Dementia - epidemiology
Female
Guam - epidemiology
Humans
Incidence
Male
Medical sciences
Middle Aged
National Institute of Neurological Disorders and Stroke
Neurology
NINDS
Parkinson Disease - complications
Parkinson Disease - epidemiology
parkinsonian disorders
parkinsonism-dementia complex
PDC
Sex Distribution
Tropical medicine
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Summary:In the 1950s, the incidence of amyotrophic lateral sclerosis (ALS, or Lytico) and parkinsonism-dementia complex (PDC, or Bodig) on the island of Guam was much higher than anywhere else in the world. From the late 1960s to the early 1980s, the incidence of both disorders has decreased. The objective of the present study was to ascertain whether the decreasing incidence continued until the end of the century (1999). The average annual incidence of ALS and PDC was calculated for each 5-year period from 1940 to 1999, utilizing registration records of all ALS and PDC cases on Guam during that period. The results of this study confirmed that the incidence of ALS declined steadily during the past 40 years. The incidence of PDC also declined until the late 1980s but, unlike ALS, showed a slight increase from 1980 to 1999. The rapid decrease in incidence is not likely to be due to genetic factors. Instead, it is most likely to be the results of radical socioeconomic, ethnographic, and ecologic changes brought about by the rapid westernization of Guam.
ISSN:0002-9262
1476-6256
0002-9262
DOI:10.1093/aje/kwf175