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Level of glycogen stores and amount of ingested glucose regulate net carbohydrate storage by different mechanisms

The respective effects of the level of glycogen stores and the size of the glucose load on the pathways of carbohydrate (CHO) metabolism were compared over the 5-hour period following glucose ingestion in normal human subjects. For this purpose, labeling of the oral glucose load with [3-3H]- and [U1...

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Published in:	Metabolism, clinical and experimental clinical and experimental, 2003-01, Vol.52 (1), p.94-101
Main Authors:	Féry, F., Plat, L., Balasse, E.O.
Format:	Article
Language:	English
Subjects:	Adult Biological and medical sciences Blood Glucose - metabolism Calorimetry, Indirect Carbohydrate Metabolism Carbohydrates Female Fundamental and applied biological sciences. Psychology Glucose - pharmacology Glucose Tolerance Test Glycogen - biosynthesis Glycogen - metabolism Glycolysis - physiology Humans Kinetics Male Metabolisms and neurohumoral controls Nutritional Status - physiology Oxidation-Reduction Postprandial Period - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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creator	Féry, F. Plat, L. Balasse, E.O.
description	The respective effects of the level of glycogen stores and the size of the glucose load on the pathways of carbohydrate (CHO) metabolism were compared over the 5-hour period following glucose ingestion in normal human subjects. For this purpose, labeling of the oral glucose load with [3-3H]- and [U14C] glucose was combined with indirect calorimetry. In group I, 75 g glucose was given to subjects who had either been “fed” with intravenous (IV) glucose or fasted for 13, 24, or 36 hours, or 4 days. In fed versus 4-day–fasted subjects, net CHO storage averaged approximately 15 versus 63 g/5 h (P
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Net storage rose from approximately −6 to ~ 37 g/5 h (P <.001) solely because of an increase in glycogen synthesis with no inhibition of glycogen turnover. Overall, these results show that the initial dietary state and the size of the glucose load modulate postprandial net CHO accumulation by different mechanisms. Copyright 2003, Elsevier Science (USA). All rights reserved.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1053/meta.2003.50015</identifier><identifier>PMID: 12524668</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Calorimetry, Indirect ; Carbohydrate Metabolism ; Carbohydrates ; Female ; Fundamental and applied biological sciences. 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subjects	Adult Biological and medical sciences Blood Glucose - metabolism Calorimetry, Indirect Carbohydrate Metabolism Carbohydrates Female Fundamental and applied biological sciences. Psychology Glucose - pharmacology Glucose Tolerance Test Glycogen - biosynthesis Glycogen - metabolism Glycolysis - physiology Humans Kinetics Male Metabolisms and neurohumoral controls Nutritional Status - physiology Oxidation-Reduction Postprandial Period - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems
title	Level of glycogen stores and amount of ingested glucose regulate net carbohydrate storage by different mechanisms
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