Loading…
Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma
Objective To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well‐differentiated thyroid carcinoma. Study Design Retrospective chart review in a tertiary care institution. Methods Two...
Saved in:
| Published in: | The Laryngoscope 2003-01, Vol.113 (1), p.77-81 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3 |
| container_end_page | 81 |
| container_issue | 1 |
| container_start_page | 77 |
| container_title | The Laryngoscope |
| container_volume | 113 |
| creator | Hall, Francis T. Beasley, Nigel J. Eski, Spiro J. Witterick, Ian J. Walfish, Paul G. Freeman, Jeremy L. |
| description | Objective To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well‐differentiated thyroid carcinoma.
Study Design Retrospective chart review in a tertiary care institution.
Methods Two hundred thirteen consecutive patients with well differentiated thyroid carcinoma treated between 1983 and 1998 were identified. Data were collected on clinicopathological variables, stimulated serum thyroglobulin levels obtained 3 months after total thyroidectomy prior to 131I therapy and recurrence.
Results A high postoperative thyroglobulin level was significantly associated with advanced‐stage disease at presentation (P = .005, Kruskall‐Wallis) but not with any of the other clinicopathological variables. Patients with a thyroglobulin level greater than 20 pmol/L had a significantly increased risk of disease recurrence on univariate analysis (n = 213 [P = .0001, log rank test]), and in the Cox proportional‐hazards model, both advanced tumor stage (P = .001, relative hazard, 3.4 [95% confidence interval [CI]: 2.4–4.9]) and a thyroglobulin level greater than 20 pmol/L (P = .001, relative hazard, 5.1 [95% CI: 2.0–13.1]) were significant predictors of recurrence. No other variables significantly altered the hazards model.
Conclusions Advanced tumor stage at diagnosis and a stimulated thyroglobulin level greater than 20 pmol/L taken 3 months after total thyroidectomy were independent predictors of disease recurrence. Patients with a thyroglobulin level greater than 20 pmol/L are at increased risk of recurrence and may be candidates for more intensive follow‐up or additional treatment. |
| doi_str_mv | 10.1097/00005537-200301000-00014 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72951241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72951241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3</originalsourceid><addsrcrecordid>eNqNkE9v1DAQxS0EotvCV6h8gVvA4z9xclxty1KxAtSWFrhYjjNuTZNNsTfAfntMs7TXWrKsGf_mzdMjhAJ7A6zWb1k-SgldcMYEg1wV-YJ8QmagBBSyrtVTMmOMi6JS_Ose2U_pRya0UOw52QOuQIqqnJEPnyO2wW3CL6QXthuRDp6eYRx7en69jcNVNzRjF9Z07jcY6dkYrzBuqR_i9B9aurDRhfXQ2xfkmbddwpe794B8eXd8vnhfrD4tTxbzVeGkZLLwLWArfYMKfVNhU2rZopJldt62OttvakRXQeNs5QXXILWsma4c47ZW2IgD8nrSvY3DzxHTxvQhOew6u8ZhTEbzWgGXkMFqAl0cUorozW0MvY1bA8z8C9L8D9LcB2nugsyjh7sdY9Nj-zC4Sy4Dr3aATc52Ptq1C-mBk9l1yVTmjibud-hw-2gDZjU__aaUBMjdOz_FJBPSBv_cy9h4Y0ottDKXH5dmUfNlWX4HsxJ_ARninIc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72951241</pqid></control><display><type>article</type><title>Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Hall, Francis T. ; Beasley, Nigel J. ; Eski, Spiro J. ; Witterick, Ian J. ; Walfish, Paul G. ; Freeman, Jeremy L.</creator><creatorcontrib>Hall, Francis T. ; Beasley, Nigel J. ; Eski, Spiro J. ; Witterick, Ian J. ; Walfish, Paul G. ; Freeman, Jeremy L.</creatorcontrib><description>Objective To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well‐differentiated thyroid carcinoma.
Study Design Retrospective chart review in a tertiary care institution.
Methods Two hundred thirteen consecutive patients with well differentiated thyroid carcinoma treated between 1983 and 1998 were identified. Data were collected on clinicopathological variables, stimulated serum thyroglobulin levels obtained 3 months after total thyroidectomy prior to 131I therapy and recurrence.
Results A high postoperative thyroglobulin level was significantly associated with advanced‐stage disease at presentation (P = .005, Kruskall‐Wallis) but not with any of the other clinicopathological variables. Patients with a thyroglobulin level greater than 20 pmol/L had a significantly increased risk of disease recurrence on univariate analysis (n = 213 [P = .0001, log rank test]), and in the Cox proportional‐hazards model, both advanced tumor stage (P = .001, relative hazard, 3.4 [95% confidence interval [CI]: 2.4–4.9]) and a thyroglobulin level greater than 20 pmol/L (P = .001, relative hazard, 5.1 [95% CI: 2.0–13.1]) were significant predictors of recurrence. No other variables significantly altered the hazards model.
Conclusions Advanced tumor stage at diagnosis and a stimulated thyroglobulin level greater than 20 pmol/L taken 3 months after total thyroidectomy were independent predictors of disease recurrence. Patients with a thyroglobulin level greater than 20 pmol/L are at increased risk of recurrence and may be candidates for more intensive follow‐up or additional treatment.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/00005537-200301000-00014</identifier><identifier>PMID: 12514386</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - analysis ; Carcinoma - blood ; Carcinoma - diagnosis ; Carcinoma - surgery ; Endocrinopathies ; Female ; Humans ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Postoperative Care ; Predictive Value of Tests ; Preoperative Care ; Probability ; Prognosis ; Radioimmunoassay ; Retrospective Studies ; Secondary Prevention ; Statistics, Nonparametric ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of endocrine glands ; Thyroglobulin ; Thyroglobulin - analysis ; Thyroglobulin - blood ; thyroid neoplasms ; Thyroid Neoplasms - blood ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - surgery ; Thyroid. Thyroid axis (diseases) ; thyroidectomy ; Thyroidectomy - adverse effects ; Thyroidectomy - methods ; Treatment Outcome</subject><ispartof>The Laryngoscope, 2003-01, Vol.113 (1), p.77-81</ispartof><rights>Copyright © 2003 The Triological Society</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3</citedby><cites>FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4040,4041,23921,23922,25131,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14474605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12514386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hall, Francis T.</creatorcontrib><creatorcontrib>Beasley, Nigel J.</creatorcontrib><creatorcontrib>Eski, Spiro J.</creatorcontrib><creatorcontrib>Witterick, Ian J.</creatorcontrib><creatorcontrib>Walfish, Paul G.</creatorcontrib><creatorcontrib>Freeman, Jeremy L.</creatorcontrib><title>Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objective To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well‐differentiated thyroid carcinoma.
Study Design Retrospective chart review in a tertiary care institution.
Methods Two hundred thirteen consecutive patients with well differentiated thyroid carcinoma treated between 1983 and 1998 were identified. Data were collected on clinicopathological variables, stimulated serum thyroglobulin levels obtained 3 months after total thyroidectomy prior to 131I therapy and recurrence.
Results A high postoperative thyroglobulin level was significantly associated with advanced‐stage disease at presentation (P = .005, Kruskall‐Wallis) but not with any of the other clinicopathological variables. Patients with a thyroglobulin level greater than 20 pmol/L had a significantly increased risk of disease recurrence on univariate analysis (n = 213 [P = .0001, log rank test]), and in the Cox proportional‐hazards model, both advanced tumor stage (P = .001, relative hazard, 3.4 [95% confidence interval [CI]: 2.4–4.9]) and a thyroglobulin level greater than 20 pmol/L (P = .001, relative hazard, 5.1 [95% CI: 2.0–13.1]) were significant predictors of recurrence. No other variables significantly altered the hazards model.
Conclusions Advanced tumor stage at diagnosis and a stimulated thyroglobulin level greater than 20 pmol/L taken 3 months after total thyroidectomy were independent predictors of disease recurrence. Patients with a thyroglobulin level greater than 20 pmol/L are at increased risk of recurrence and may be candidates for more intensive follow‐up or additional treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - surgery</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Care</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Radioimmunoassay</subject><subject>Retrospective Studies</subject><subject>Secondary Prevention</subject><subject>Statistics, Nonparametric</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of endocrine glands</subject><subject>Thyroglobulin</subject><subject>Thyroglobulin - analysis</subject><subject>Thyroglobulin - blood</subject><subject>thyroid neoplasms</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>thyroidectomy</subject><subject>Thyroidectomy - adverse effects</subject><subject>Thyroidectomy - methods</subject><subject>Treatment Outcome</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkE9v1DAQxS0EotvCV6h8gVvA4z9xclxty1KxAtSWFrhYjjNuTZNNsTfAfntMs7TXWrKsGf_mzdMjhAJ7A6zWb1k-SgldcMYEg1wV-YJ8QmagBBSyrtVTMmOMi6JS_Ose2U_pRya0UOw52QOuQIqqnJEPnyO2wW3CL6QXthuRDp6eYRx7en69jcNVNzRjF9Z07jcY6dkYrzBuqR_i9B9aurDRhfXQ2xfkmbddwpe794B8eXd8vnhfrD4tTxbzVeGkZLLwLWArfYMKfVNhU2rZopJldt62OttvakRXQeNs5QXXILWsma4c47ZW2IgD8nrSvY3DzxHTxvQhOew6u8ZhTEbzWgGXkMFqAl0cUorozW0MvY1bA8z8C9L8D9LcB2nugsyjh7sdY9Nj-zC4Sy4Dr3aATc52Ptq1C-mBk9l1yVTmjibud-hw-2gDZjU__aaUBMjdOz_FJBPSBv_cy9h4Y0ottDKXH5dmUfNlWX4HsxJ_ARninIc</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Hall, Francis T.</creator><creator>Beasley, Nigel J.</creator><creator>Eski, Spiro J.</creator><creator>Witterick, Ian J.</creator><creator>Walfish, Paul G.</creator><creator>Freeman, Jeremy L.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200301</creationdate><title>Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma</title><author>Hall, Francis T. ; Beasley, Nigel J. ; Eski, Spiro J. ; Witterick, Ian J. ; Walfish, Paul G. ; Freeman, Jeremy L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - surgery</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Care</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Radioimmunoassay</topic><topic>Retrospective Studies</topic><topic>Secondary Prevention</topic><topic>Statistics, Nonparametric</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of endocrine glands</topic><topic>Thyroglobulin</topic><topic>Thyroglobulin - analysis</topic><topic>Thyroglobulin - blood</topic><topic>thyroid neoplasms</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>thyroidectomy</topic><topic>Thyroidectomy - adverse effects</topic><topic>Thyroidectomy - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hall, Francis T.</creatorcontrib><creatorcontrib>Beasley, Nigel J.</creatorcontrib><creatorcontrib>Eski, Spiro J.</creatorcontrib><creatorcontrib>Witterick, Ian J.</creatorcontrib><creatorcontrib>Walfish, Paul G.</creatorcontrib><creatorcontrib>Freeman, Jeremy L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hall, Francis T.</au><au>Beasley, Nigel J.</au><au>Eski, Spiro J.</au><au>Witterick, Ian J.</au><au>Walfish, Paul G.</au><au>Freeman, Jeremy L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2003-01</date><risdate>2003</risdate><volume>113</volume><issue>1</issue><spage>77</spage><epage>81</epage><pages>77-81</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objective To determine the relationship between stimulated serum thyroglobulin levels (taken 3 months after total thyroidectomy) and tumor stage and recurrence in patients with well‐differentiated thyroid carcinoma.
Study Design Retrospective chart review in a tertiary care institution.
Methods Two hundred thirteen consecutive patients with well differentiated thyroid carcinoma treated between 1983 and 1998 were identified. Data were collected on clinicopathological variables, stimulated serum thyroglobulin levels obtained 3 months after total thyroidectomy prior to 131I therapy and recurrence.
Results A high postoperative thyroglobulin level was significantly associated with advanced‐stage disease at presentation (P = .005, Kruskall‐Wallis) but not with any of the other clinicopathological variables. Patients with a thyroglobulin level greater than 20 pmol/L had a significantly increased risk of disease recurrence on univariate analysis (n = 213 [P = .0001, log rank test]), and in the Cox proportional‐hazards model, both advanced tumor stage (P = .001, relative hazard, 3.4 [95% confidence interval [CI]: 2.4–4.9]) and a thyroglobulin level greater than 20 pmol/L (P = .001, relative hazard, 5.1 [95% CI: 2.0–13.1]) were significant predictors of recurrence. No other variables significantly altered the hazards model.
Conclusions Advanced tumor stage at diagnosis and a stimulated thyroglobulin level greater than 20 pmol/L taken 3 months after total thyroidectomy were independent predictors of disease recurrence. Patients with a thyroglobulin level greater than 20 pmol/L are at increased risk of recurrence and may be candidates for more intensive follow‐up or additional treatment.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>12514386</pmid><doi>10.1097/00005537-200301000-00014</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2003-01, Vol.113 (1), p.77-81 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72951241 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - analysis Carcinoma - blood Carcinoma - diagnosis Carcinoma - surgery Endocrinopathies Female Humans Male Malignant tumors Medical sciences Middle Aged Postoperative Care Predictive Value of Tests Preoperative Care Probability Prognosis Radioimmunoassay Retrospective Studies Secondary Prevention Statistics, Nonparametric Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of endocrine glands Thyroglobulin Thyroglobulin - analysis Thyroglobulin - blood thyroid neoplasms Thyroid Neoplasms - blood Thyroid Neoplasms - diagnosis Thyroid Neoplasms - surgery Thyroid. Thyroid axis (diseases) thyroidectomy Thyroidectomy - adverse effects Thyroidectomy - methods Treatment Outcome |
| title | Predictive Value of Serum Thyroglobulin After Surgery for Thyroid Carcinoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T06%3A16%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictive%20Value%20of%20Serum%20Thyroglobulin%20After%20Surgery%20for%20Thyroid%20Carcinoma&rft.jtitle=The%20Laryngoscope&rft.au=Hall,%20Francis%20T.&rft.date=2003-01&rft.volume=113&rft.issue=1&rft.spage=77&rft.epage=81&rft.pages=77-81&rft.issn=0023-852X&rft.eissn=1531-4995&rft.coden=LARYA8&rft_id=info:doi/10.1097/00005537-200301000-00014&rft_dat=%3Cproquest_cross%3E72951241%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4404-fd1ed4fbe5efb8eb674de546153dd7531b9eec81bca8f32714749078c02a95eb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=72951241&rft_id=info:pmid/12514386&rfr_iscdi=true |