Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×10 6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary ar...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2003-01, Vol.361 (9351), p.45-46
Main Authors: Stamm, Christof, Westphal, Bernd, Kleine, Hans-Dieter, Petzsch, Michael, Kittner, Christian, Klinge, Heiko, Schümichen, Carl, Nienaber, Christoph A, Freund, Mathias, Steinhoff, Gustav
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary
Cardiovascular Agents - therapeutic use
Coronary Artery Bypass
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Myocardial Infarction - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×10 6 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(03)12110-1