Autotransplanted Jejunum in Patients with Carcinomas of the Head and Neck: Transport of Immunosurveillance against Tumor Cells?

Autologous jejunum, transplanted as a functional replacement immediately after radical dissection of advanced stages of squamous cell carcinomas of the head and neck and subsequently irradiated, was examined by immunohistochemistry (APAAP/PAP-technique). Biopsies from 9 patients were taken at the ti...

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Bibliographic Details
Published in:Immunobiology (1979) 1992-04, Vol.184 (4), p.321-335
Main Authors: Kornfehl, Johannes, Neuchrist, Csilla, Grasl, Matthäus C., Piza, Hildegunde, Roka, Rudolf, Ehrenberger, Klaus, Sorg, Clemens, Kraft, Dietrich, Scheiner, Otto
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal
Antigens, CD - immunology
Antigens, Surface - immunology
B-Lymphocytes - immunology
Biological and medical sciences
Biological Transport
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - surgery
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - radiotherapy
Head and Neck Neoplasms - surgery
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Immunoenzyme Techniques
Jejunum - transplantation
Macrophages - immunology
Male
Medical sciences
Middle Aged
Monitoring, Immunologic
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the upper aerodigestive tract
T-Lymphocytes - immunology
Transplantation, Autologous - immunology
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Summary:Autologous jejunum, transplanted as a functional replacement immediately after radical dissection of advanced stages of squamous cell carcinomas of the head and neck and subsequently irradiated, was examined by immunohistochemistry (APAAP/PAP-technique). Biopsies from 9 patients were taken at the time of transplantation and up to 24 months thereafter (group 1) and from 5 patients only once after transplantation (group 2). Twenty-six monoclonal antibodies (mAbs) were used as surface markers to give an overview about phenotypical changes with respect to T-, B-and MФ-antigens. 1) B cells: a general increase of CR2 + (CD21, p
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(11)80590-5